CIMOXATONE

Details

Stereochemistry	RACEMIC
Molecular Formula	C19H18N2O4
Molecular Weight	338.3572
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COCC1CN(C(=O)O1)C2=CC=C(OCC3=CC=CC(=C3)C#N)C=C2

InChI

InChIKey=MVVJINIUPYKZHR-UHFFFAOYSA-N

InChI=1S/C19H18N2O4/c1-23-13-18-11-21(19(22)25-18)16-5-7-17(8-6-16)24-12-15-4-2-3-14(9-15)10-20/h2-9,18H,11-13H2,1H3

HIDE SMILES / InChI

Molecular Formula	C19H18N2O4
Molecular Weight	338.3572
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6822834 | https://www.ncbi.nlm.nih.gov/pubmed/6698662 | https://www.ncbi.nlm.nih.gov/pubmed/2412251

Cimoxatone is a fully reversible inhibitor selective for the A form of monoamine oxidase. Oral administration of Cimoxatone increased brain noradrenaline, dopamine, and serotonin and decreased DOPAC , 5-HIAA, and 3-methoxy-4-hydroxyphenylethylene glycol sulfate.

CNS Activity

Approval Year

PubMed

Title	Date	PubMed
Some biochemical aspects of the potential benefit of associating MD780515 with tricyclic antidepressants.	1981 Oct	6117616
Neuropharmacological profile of MD 780515, a new reversible inhibitor of type A monoamine oxidase.	1982 Oct	6129835
SL25.1131 [3(S),3a(S)-3-methoxymethyl-7-[4,4,4-trifluorobutoxy]-3,3a,4,5-tetrahydro-1,3-oxazolo[3,4-a]quinolin-1-one], a new, reversible, and mixed inhibitor of monoamine oxidase-A and monoamine oxidase-B: biochemical and behavioral profile.	2004 Sep	15178694

Patents

Sample Use Guides

In Vivo Use Guide

40 mg as a single dose

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:16:45 GMT 2023` Edited by `admin` on `Fri Dec 15 15:16:45 GMT 2023`
Record UNII	V6FT1QJ7VL
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

CIMOXATONE

Official Name

English

CIMOXATONE [MART.]

Common Name

English

.ALPHA.-(P-(5-(METHOXYMETHYL)-2-OXO-3-OXAZOLIDINYL)PHENOXY)-M-TOLUNITRILE

Common Name

English

cimoxatone [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C667