TELPEGFILGRASTIM

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 08:24:03 GMT 2025` Edited by `admin` on `Wed Apr 02 08:24:03 GMT 2025`
Protein Type	CYTOKINE
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	V2ZD052TS1
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TELPEGFILGRASTIM

Official Name

English

telpegfilgrastim [INN]

Preferred Name

English

HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR (G-CSF, PLURIPOIETIN) SHORT ISOFORM, VARIANT (A1>M), PRODUCED IN ESCHERICHIA COLI, PEGYLATED WITH ONE N-((.ALPHA.-METHYLPOLY(OXYETHYLENE)-.OMEGA.-OXY)ACETYL)-N-(.ALPHA.-METHYLPOLY(OXYETHYLENE)-.OMEGA.-YL)GLYCYL

Common Name

English

Telpegfilgrastim [WHO-DD]

Common Name

English

POLY(OXY-1,2-ETHANEDIYL), .ALPHA.-HYDRO-.OMEGA.-METHOXY-, ETHER WITH N-(2-HYDROXYACETYL)-N-(2-HYDROXYETHYL)GLYCINE(2:1), 1,176 DIAMIDE WITH GRANULOCYTE COLONY-STIMULATING FACTOR (1-METHIONINE) (HUMAN SHORT ISOFORM) (2MPEG450)

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C175860

Created by admin on Wed Apr 02 08:24:03 GMT 2025 , Edited by admin on Wed Apr 02 08:24:03 GMT 2025

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SMS_ID

300000033654

Created by admin on Wed Apr 02 08:24:03 GMT 2025 , Edited by admin on Wed Apr 02 08:24:03 GMT 2025

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FDA UNII

V2ZD052TS1

Created by admin on Wed Apr 02 08:24:03 GMT 2025 , Edited by admin on Wed Apr 02 08:24:03 GMT 2025

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INN

11432

Created by admin on Wed Apr 02 08:24:03 GMT 2025 , Edited by admin on Wed Apr 02 08:24:03 GMT 2025

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CAS

2325436-66-4

Created by admin on Wed Apr 02 08:24:03 GMT 2025 , Edited by admin on Wed Apr 02 08:24:03 GMT 2025

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From	To
1_65	1_75
1_37	1_43

Related Record Type Details


					V2ZD052TS1

TELPEGFILGRASTIM

ACTIVE MOIETY

Comments:

granulocyte colony-stimulating factor (G-CSF) analogue

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1]	N-TERMINUS		Amount:	N-(N-MPEG-450-N-OXOMETHYL-MPEG-450-GLYCINYL)METHIONINE	I66VB45UZ2
AMINO_ACID_SUBSTITUTION	[1_17]			Amount:	N6-(N-MPEG-450-N-OXOMETHYL-MPEG-450-GLYCINYL)LYSINE	X3WVU1R7FZ
AMINO_ACID_SUBSTITUTION	[1_24] [1_35] [1_41]	SITE_SPECIFIC		Amount:	N6-(N-MPEG-450-N-OXOMETHYL-MPEG-450-GLYCINYL)LYSINE	X3WVU1R7FZ

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL

Molecular Formula	CHEMICAL