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Details

Stereochemistry ABSOLUTE
Molecular Formula C40H48N2O6
Molecular Weight 652.8189
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 2

SHOW SMILES / InChI
Structure of METOCURINE

SMILES

COC1=CC=C2C[C@@H]3C4=C(OC5=CC=C(C[C@H]6C7=C(CC[N+]6(C)C)C=C(OC)C(OC1=C2)=C7)C=C5)C(OC)=C(OC)C=C4CC[N+]3(C)C

InChI

InChIKey=JFXBEKISTKFVAB-AJQTZOPKSA-N
InChI=1S/C40H48N2O6/c1-41(2)17-15-27-22-34(44-6)36-24-30(27)31(41)19-25-9-12-29(13-10-25)47-40-38-28(23-37(45-7)39(40)46-8)16-18-42(3,4)32(38)20-26-11-14-33(43-5)35(21-26)48-36/h9-14,21-24,31-32H,15-20H2,1-8H3/q+2/t31-,32+/m0/s1

HIDE SMILES / InChI

Molecular Formula C40H48N2O6
Molecular Weight 652.8189
Charge 2
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry MIXED
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Metocurine, also known as dimethyltubocurarine, is a non-depolarizing muscle relaxant through the neuromuscular blockade. It antagonizes the neurotransmitter action of acetylcholine by binding competitively with cholinergic receptor sites on the motor end-plate. Patients chronically receiving anticonvulsants are relatively resistant to metocurine.

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
METOCURINE IODIDE

Cmax

ValueDoseCo-administeredAnalytePopulation
0.46 μg/mL
0.3 mg/kg single, intravenous
METOCURINE serum
Homo sapiens
1.05 μg/mL
0.3 mg/kg single, intravenous
METOCURINE serum
Homo sapiens

T1/2

ValueDoseCo-administeredAnalytePopulation
6 h
0.3 mg/kg single, intravenous
METOCURINE serum
Homo sapiens
11.4 h
0.3 mg/kg single, intravenous
METOCURINE serum
Homo sapiens

Sourcing

PubMed

Substance Class Chemical
Record UNII
V0M92G2U26
Record Status Validated (UNII)
Record Version