Details
| Stereochemistry | EPIMERIC |
| Molecular Formula | C16H21NO3.C8H6O4 |
| Molecular Weight | 441.4737 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 3 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)C1=CC=C(C=C1)C(O)=O.CN2[C@H]3CC[C@@H]2C[C@@H](C3)OC(=O)C(O)C4=CC=CC=C4
InChI
InChIKey=GZOBYLKCMLZSCM-RDYJJYPNSA-N
InChI=1S/C16H21NO3.C8H6O4/c1-17-12-7-8-13(17)10-14(9-12)20-16(19)15(18)11-5-3-2-4-6-11;9-7(10)5-1-2-6(4-3-5)8(11)12/h2-6,12-15,18H,7-10H2,1H3;1-4H,(H,9,10)(H,11,12)/t12-,13+,14+,15?;
| Molecular Formula | C16H21NO3 |
| Molecular Weight | 275.3428 |
| Charge | 0 |
| Count |
|
| Stereochemistry | EPIMERIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 3 / 4 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
| Molecular Formula | C8H6O4 |
| Molecular Weight | 166.1308 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Palliative | HYDROCODONE BITARTRATE AND HOMATROPINE METHYLBROMIDE Approved UseHydrocodone bitartrate and homatropine methylbromide syrup is indicated for the symptomatic relief of cough. Launch Date4.15497585E11 |
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Neurological manifestations in the intoxication of infants by dimethicone combined with homatropine: report of 6 cases]. | 2001 Jun |
|
| Contact allergy to atropine and other mydriatic agents in eye drops. | 2001 Nov |
|
| Corneal topographic changes following retinal surgery. | 2004 Aug 3 |
|
| Evaluation of amniotic membrane transplantation as an adjunct to medical therapy as compared with medical therapy alone in acute ocular burns. | 2005 Nov |
|
| Intramuscular ophthalmic homatropine vs. atropine to prevent lethality in rates with dichlorvos poisoning. | 2006 Dec |
|
| Role of the medial prefrontal cortex in cardiovascular responses to acute restraint in rats. | 2006 Nov 17 |
|
| Pretreating rats with parenteral ophthalmic antimuscarinic agents decreases mortality from lethal organophosphate poisoning. | 2007 Apr |
|
| Enantioseparation of chiral tropa alkaloids by means of cyclodextrin-modified microemulsion electrokinetic chromatography. | 2007 Aug |
|
| True moving bed electrophoresis using stepped electric field gradients. | 2007 May |
|
| An "epidemic" of post cataract surgery endophthalmitis by a new organism. | 2007 Nov-Dec |
|
| Metoclopramide protection of diazinon-induced toxicosis in chickens. | 2007 Sep |
|
| Granuloma annulare anterior uveitis. | 2008 Jan-Feb |
|
| Syphilitic palmoplantar keratoderma and ocular disease: a rare combination in an HIV-positive patient. | 2009 Dec |
|
| Two differing presentations of chronic bilateral anterior uveitis. | 2009 Feb |
|
| Role of the bed nucleus of the stria terminalis in the cardiovascular responses to acute restraint stress in rats. | 2009 May |
|
| The endogenous cannabinoid, anandamide, inhibits dopamine transporter function by a receptor-independent mechanism. | 2010 Mar |
|
| Acute postoperative endophthalmitis by Gemella haemolysans. | 2010 May-Jun |
|
| Homocysteinethiolactone and paraoxonase: novel markers of diabetic retinopathy. | 2010 Sep |
|
| Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. | 2011 Jul 14 |
Sample Use Guides
Adults and Adolescents 12 Years of Age and Older: 1 tablet or 5 mL (1 teaspoonful) of the oral solution every 4 to 6 hours as needed; do not exceed 6 tablets or 30 mL (6 teaspoonfuls) in 24 hours. Children 6 to 11 Years of Age: 1/2 tablet or 2.5 mL (1/2 teaspoonful) of the oral solution every 4 to 6 hours as needed; do not exceed 3 tablets or 15 mL (3 teaspoonfuls) in 24 hours.
Route of Administration:
Oral
Isolated caprine urinary bladder detrusor muscle strips were incubated with homatropine at 5 uM after being contracted with 100 mum acetylcholine. The drug inhibited the ACh-induced contraction of the caprine detrusor and that this inhibition was reversed by raising the concentration of ACh.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 16 16:49:19 UTC 2022
by
admin
on
Fri Dec 16 16:49:19 UTC 2022
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| Record UNII |
UWG9VR2QJC
|
| Record Status |
Validated (UNII)
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| Record Version |
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71587072
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SUB02532MIG
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admin on Fri Dec 16 16:49:19 UTC 2022 , Edited by admin on Fri Dec 16 16:49:19 UTC 2022
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UWG9VR2QJC
Created by
admin on Fri Dec 16 16:49:19 UTC 2022 , Edited by admin on Fri Dec 16 16:49:19 UTC 2022
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PARENT -> SALT/SOLVATE |
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ACTIVE MOIETY |