Details
| Stereochemistry | EPIMERIC |
| Molecular Formula | C16H21NO3.C8H6O4 |
| Molecular Weight | 441.4737 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 3 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)C1=CC=C(C=C1)C(O)=O.CN2[C@H]3CC[C@@H]2C[C@@H](C3)OC(=O)C(O)C4=CC=CC=C4
InChI
InChIKey=GZOBYLKCMLZSCM-RDYJJYPNSA-N
InChI=1S/C16H21NO3.C8H6O4/c1-17-12-7-8-13(17)10-14(9-12)20-16(19)15(18)11-5-3-2-4-6-11;9-7(10)5-1-2-6(4-3-5)8(11)12/h2-6,12-15,18H,7-10H2,1H3;1-4H,(H,9,10)(H,11,12)/t12-,13+,14+,15?;
| Molecular Formula | C8H6O4 |
| Molecular Weight | 166.1308 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C16H21NO3 |
| Molecular Weight | 275.3428 |
| Charge | 0 |
| Count |
|
| Stereochemistry | EPIMERIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 3 / 4 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Palliative | HYDROCODONE BITARTRATE AND HOMATROPINE METHYLBROMIDE Approved UseHydrocodone bitartrate and homatropine methylbromide syrup is indicated for the symptomatic relief of cough. Launch Date4.15497585E11 |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Buspirone, but not sumatriptan, induces miosis in humans: relevance for a serotoninergic pupil control. | 1995 Mar |
|
| Herpes simplex virus type 1 associated acute retinal necrosis following encephalitis. | 2001 |
|
| [Neurological manifestations in the intoxication of infants by dimethicone combined with homatropine: report of 6 cases]. | 2001 Jun |
|
| Topical ketorolac tromethamine 0.5% versus diclofenac sodium 0.1% to inhibit miosis during cataract surgery. | 2002 Mar |
|
| Microbial keratitis and vision loss with contact lenses. | 2003 Jan |
|
| Acute posterior multifocal placoid pigment epitheliopathy after meningococcal C conjugate vaccine. | 2005 Apr |
|
| Frontotemporal dementia with co-occurrence of astrocytic plaques and tufted astrocytes, and severe degeneration of the cerebral white matter: a variant of corticobasal degeneration? | 2005 Mar |
|
| Enantioseparation of chiral tropa alkaloids by means of cyclodextrin-modified microemulsion electrokinetic chromatography. | 2007 Aug |
|
| Metoclopramide protection of diazinon-induced toxicosis in chickens. | 2007 Sep |
|
| Acute retinal necrosis complicating chickenpox in a healthy adult--a case report and review of literature. | 2007 Spring |
|
| Managing corneal disease: focus on suppurative keratitis. | 2009 Dec |
|
| Keratouveitis caused by Euphorbia plant sap. | 2009 Jul-Aug |
|
| The endogenous cannabinoid, anandamide, inhibits dopamine transporter function by a receptor-independent mechanism. | 2010 Mar |
|
| Refractive error and visual functions in children with special needs compared with the first grade school students in oman. | 2010 Oct |
|
| Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. | 2011 Jul 14 |
Sample Use Guides
Adults and Adolescents 12 Years of Age and Older: 1 tablet or 5 mL (1 teaspoonful) of the oral solution every 4 to 6 hours as needed; do not exceed 6 tablets or 30 mL (6 teaspoonfuls) in 24 hours. Children 6 to 11 Years of Age: 1/2 tablet or 2.5 mL (1/2 teaspoonful) of the oral solution every 4 to 6 hours as needed; do not exceed 3 tablets or 15 mL (3 teaspoonfuls) in 24 hours.
Route of Administration:
Oral
Isolated caprine urinary bladder detrusor muscle strips were incubated with homatropine at 5 uM after being contracted with 100 mum acetylcholine. The drug inhibited the ACh-induced contraction of the caprine detrusor and that this inhibition was reversed by raising the concentration of ACh.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:19:54 UTC 2023
by
admin
on
Fri Dec 15 15:19:54 UTC 2023
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| Record UNII |
UWG9VR2QJC
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| Record Status |
Validated (UNII)
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| Record Version |
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71587072
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SUB02532MIG
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UWG9VR2QJC
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100000086706
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PARENT -> SALT/SOLVATE |
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ACTIVE MOIETY |