U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C6H8O7.Fe.H3N
Molecular Weight 264.999
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 3

SHOW SMILES / InChI
Structure of FERRIC AMMONIUM CITRATE

SMILES

N.[Fe+3].OC(=O)CC(O)(CC(O)=O)C(O)=O

InChI

InChIKey=FRHBOQMZUOWXQL-UHFFFAOYSA-N
InChI=1S/C6H8O7.Fe.H3N/c7-3(8)1-6(13,5(11)12)2-4(9)10;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;1H3/q;+3;

HIDE SMILES / InChI
Molecular Formula C6H5O7
Molecular Weight 189.0997
Charge -3
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula Fe
Molecular Weight 55.845
Charge 3
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula H3N
Molecular Weight 17.0305
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including http://www.mfc.co.jp/english/eng/product/sanferol/index.html

Ferric Ammonium EDTA Solution is normally used as a photographic chemical for a bleaching agent in the process of colour washing. It is also used as a complexing, and oxidizing agent & as a fertilizer and catalyst. EDTA acid are colourless, water-soluble solid that are widely used to dissolve scale. The usefulness of these ammonium salts arise because of its role as a chelating agent, i.e. its ability to "sequester" metal ions such as Ca2+ and Fe3+.

Originator

Monsanto Chemicals
40
Curator's Comment: The relation between phosphate level and ferric citrate consumption was first discovered in 1940s.

Approval Year

1921
1468
Targets

Targets

Primary TargetPharmacologyConditionPotency
Activator
1447
Chelating Agent
139
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Basic research
Unknown

Approved Use

Unknown
Primary
Approved
8583
SANFEROL

Approved Use

It has also been reported that SFC preparation improved iron deficiency in a pregnant woman with iron deficiency anemia whose hemoglobin level had not increased after administration of other iron preparations such as ferrous fumarate. A dairy supplemental dose of SFC improved iron deficiency in young women with iron deficiency.
Inactive ingredient
Approved
8583
Oxycontin

Approved Use

OxyContin is used in the treatment of chronic pain; pain and belongs to the drug class narcotic analgesics.

Launch Date

1998
Palliative
Approved
8583
AURYXIA

Approved Use

Ferric Citrate is a phosphate binder indicated for the control of serum phosphorus levels in patients with chronic kidney disease on dialysis.

Launch Date

2014
PubMed

PubMed

TitleDatePubMed
Phosphorus recovery from biogas slurry by ultrasound/H2O2 digestion coupled with HFO/biochar adsorption process.
2017-02
Superior electrochemical performance of N-doped nanocrystalline FeF3/C with a single-step solid-state process.
2016-10-04
Heme Binding by Corynebacterium diphtheriae HmuT: Function and Heme Environment.
2015-11-03
Microwave assisted convenient one-pot synthesis of coumarin derivatives via Pechmann condensation catalyzed by FeF3 under solvent-free conditions and antimicrobial activities of the products.
2014-08-26
FeF(3) catalyzed cascade C-C and C-N bond formation: synthesis of differentially substituted triheterocyclic benzothiazole functionalities under solvent-free condition.
2014-05
Finnish wallpaper pigments in the 18th-19th century: presence of KFe3(CrO4)2(OH)6 and odd pigment mixtures.
2013-04
Thermal behavior study and decomposition kinetics of amiodarone hydrochloride under isothermal conditions.
2011-06
Fabrication of FeF3 Nanoflowers on CNT branches and their application to high power lithium rechargeable batteries.
2010-12-07
Interaction of omapatrilat with FD&C Blue No. 2 lake during dissolution of modified release tablets.
2007-07-18
Non-invasive and non-destructive micro-XRF and micro-Raman analysis of a decorative wallpaper from the beginning of the 19th century.
2007-02
New phosphate binding agents: ferric compounds.
1999-06
Effect of physical exercise and vitamin C on absorption of ferric sodium citrate.
1996-12
Carcinogenicity studies on natural and man-made fibres with the intraperitoneal test in rats.
1989
Contact dermatitis to yellow iron oxide.
1985-08
Biological availability of iron supplements for rats, chicks and humans.
1976-02
The absorption of iron as supplements in infant cereal and infant formulas.
1975-05
The formation of ferritin from apoferritin. Catalytic action of apoferritin.
1973-10
The formation of ferritin from apoferritin. Kinetics and mechanism of iron uptake.
1972-01
[Effects of ferric fluoride compounds on dental enamel].
1954-11-15
Patents

Patents

20090216060
40
6258758
40
US 5206265 A
40
US2385188
40
US4364871
40
US6881255
40
US6903235
40
US7198668
40

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Iron oxides black, red and yellow are intended to be used as colourants in feedingstuffs for all animal species without dose or age restriction. The applicant recommends 500–1,200 mg/kg of the additives in complete (and complementary) feedingstuffs as standard dose. http://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2016.4482/full
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Bovine enamel was treated with 10 mM FeF3 (Ferric fluoride)
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:03:52 GMT 2025
Edited
by admin
on Mon Mar 31 18:03:52 GMT 2025
Record UNII
UVP74NG1C5
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FERRIC AMMONIUM CITRATE
HSDB   INCI   JAN   MART.   MI   ORANGE BOOK   USP   VANDF   WHO-DD  
INCI  
Official Name English
FERRIC AMMONIUM CITRATE, GREEN
FCC   VANDF  
Preferred Name English
COMPOUNDS OF NH3, IRON, AND CITRIC ACID OF UNDETERMINED FORMULA AND STRUCTURE
Common Name English
FERRIC AMMONIUM CITRATE [VANDF]
Common Name English
AMMONIUM IRON CITRATE
Systematic Name English
FERRIC AMMONIUM CITRATE [USP]
Common Name English
E 381
Code English
FERRIC AMMONIUM CITRATE, BROWN
FCC  
Common Name English
FERRIC AMMONIUM CITRATE, GREEN [VANDF]
Common Name English
IRON(III) AMMONIUM CITRATE
Systematic Name English
FERRIC AMMONIUM CITRATE [USP MONOGRAPH]
Common Name English
INS-381
Common Name English
FERRISELTZ
Brand Name English
2-HYDROXY-1,2,3-PROPANETRICARBOXYLIC ACID AMMONIUM IRON (3+) SALT
Common Name English
FERRIC AMMONIUM CITRATE, BROWN [FCC]
Common Name English
INS NO.381
Common Name English
FERRIC AMMONIUM CITRATE [MART.]
Common Name English
FERRIC AMMONIUM CITRATE,GREEN
VANDF  
Common Name English
FERRIC AMMONIUM CITRATE, GREEN [FCC]
Common Name English
FERRIC AMMONIUM CITRATE,GREEN [VANDF]
Common Name English
FERRIC AMMONIUM CITRATE [JAN]
Common Name English
IRON AMMONIUM CITRATE
Systematic Name English
FERRIC AMMONIUM CITRATE CONTAINS NOT LESS THAN 16.5 PERCENT AND NOT MORE THAN 18.5 PERCENT OF IRON
Common Name English
FERRIC AMMONIUM CITRATE [MI]
Common Name English
FERRIC AMMONIUM CITRATE [ORANGE BOOK]
Common Name English
AMMONIUM IRON(3+) CITRATE
Systematic Name English
AMMONIUM IRON (III) CITRATE
Systematic Name English
FERRIC AMMONIUM CITRATE [HSDB]
Common Name English
E-381
Code English
AMMONIUM FERRIC CITRATE
Common Name English
Ferric ammonium citrate [WHO-DD]
Common Name English
Classification Tree Code System Code
CFR 21 CFR 184.1296
Created by admin on Mon Mar 31 18:03:52 GMT 2025 , Edited by admin on Mon Mar 31 18:03:52 GMT 2025
CFR 21 CFR 172.430
Created by admin on Mon Mar 31 18:03:52 GMT 2025 , Edited by admin on Mon Mar 31 18:03:52 GMT 2025
WHO-VATC QV08CA07
Created by admin on Mon Mar 31 18:03:52 GMT 2025 , Edited by admin on Mon Mar 31 18:03:52 GMT 2025
JECFA EVALUATION INS-381
Created by admin on Mon Mar 31 18:03:52 GMT 2025 , Edited by admin on Mon Mar 31 18:03:52 GMT 2025
CODEX ALIMENTARIUS (GSFA) INS-381
Created by admin on Mon Mar 31 18:03:52 GMT 2025 , Edited by admin on Mon Mar 31 18:03:52 GMT 2025
WHO-ATC V08CA07
Created by admin on Mon Mar 31 18:03:52 GMT 2025 , Edited by admin on Mon Mar 31 18:03:52 GMT 2025
Code System Code Type Description
DRUG BANK
DB09501
Created by admin on Mon Mar 31 18:03:52 GMT 2025 , Edited by admin on Mon Mar 31 18:03:52 GMT 2025
PRIMARY
HSDB
446
Created by admin on Mon Mar 31 18:03:52 GMT 2025 , Edited by admin on Mon Mar 31 18:03:52 GMT 2025
PRIMARY
EVMPD
SUB13834MIG
Created by admin on Mon Mar 31 18:03:52 GMT 2025 , Edited by admin on Mon Mar 31 18:03:52 GMT 2025
PRIMARY
DAILYMED
UVP74NG1C5
Created by admin on Mon Mar 31 18:03:52 GMT 2025 , Edited by admin on Mon Mar 31 18:03:52 GMT 2025
PRIMARY
WIKIPEDIA
AMMONIUM FERRIC CITRATE
Created by admin on Mon Mar 31 18:03:52 GMT 2025 , Edited by admin on Mon Mar 31 18:03:52 GMT 2025
PRIMARY
SMS_ID
100000088543
Created by admin on Mon Mar 31 18:03:52 GMT 2025 , Edited by admin on Mon Mar 31 18:03:52 GMT 2025
PRIMARY
MERCK INDEX
m5314
Created by admin on Mon Mar 31 18:03:52 GMT 2025 , Edited by admin on Mon Mar 31 18:03:52 GMT 2025
PRIMARY Merck Index
PUBCHEM
2724226
Created by admin on Mon Mar 31 18:03:52 GMT 2025 , Edited by admin on Mon Mar 31 18:03:52 GMT 2025
PRIMARY
ChEMBL
CHEMBL1200460
Created by admin on Mon Mar 31 18:03:52 GMT 2025 , Edited by admin on Mon Mar 31 18:03:52 GMT 2025
PRIMARY
CAS
1185-57-5
Created by admin on Mon Mar 31 18:03:52 GMT 2025 , Edited by admin on Mon Mar 31 18:03:52 GMT 2025
PRIMARY
MESH
C013531
Created by admin on Mon Mar 31 18:03:52 GMT 2025 , Edited by admin on Mon Mar 31 18:03:52 GMT 2025
PRIMARY
ECHA (EC/EINECS)
214-686-6
Created by admin on Mon Mar 31 18:03:52 GMT 2025 , Edited by admin on Mon Mar 31 18:03:52 GMT 2025
PRIMARY
CHEBI
31604
Created by admin on Mon Mar 31 18:03:52 GMT 2025 , Edited by admin on Mon Mar 31 18:03:52 GMT 2025
PRIMARY
FDA UNII
UVP74NG1C5
Created by admin on Mon Mar 31 18:03:52 GMT 2025 , Edited by admin on Mon Mar 31 18:03:52 GMT 2025
PRIMARY
RXCUI
24897
Created by admin on Mon Mar 31 18:03:52 GMT 2025 , Edited by admin on Mon Mar 31 18:03:52 GMT 2025
PRIMARY RxNorm
Related Record Type Details
Structure of FERRIC CATION
ACTIVE MOIETY
NIH
NCATS
PRIVACY NOTICE
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966