AMLIVIRSEN

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Sat Dec 16 14:11:15 UTC 2023` Edited by `admin` on `Sat Dec 16 14:11:15 UTC 2023`
Nucleic Acid Subtype
Record UNII	UU75G79NK3
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AMLIVIRSEN

Official Name

English

amlivirsen [INN]

Common Name

English

DNA, D(P-THIO)((2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))RA-G-G-T-G-A-A-G-M5C-G-A-(2'-O-(2-METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))M5RU-(2'-O

Systematic Name

English

Code System Code Type Description

CAS

1637640-12-0

Created by admin on Sat Dec 16 14:11:15 UTC 2023 , Edited by admin on Sat Dec 16 14:11:15 UTC 2023

PRIMARY

NCI_THESAURUS

C169782

Created by admin on Sat Dec 16 14:11:15 UTC 2023 , Edited by admin on Sat Dec 16 14:11:15 UTC 2023

PRIMARY

INN

10899

Created by admin on Sat Dec 16 14:11:15 UTC 2023 , Edited by admin on Sat Dec 16 14:11:15 UTC 2023

PRIMARY

FDA UNII

UU75G79NK3

Created by admin on Sat Dec 16 14:11:15 UTC 2023 , Edited by admin on Sat Dec 16 14:11:15 UTC 2023

PRIMARY

Sugar	Site Range	Site Count
2'-O-Methoxyethyl ribose	1_1-1_5;1_16-1_20	10 / 20
Deoxyribose (DNA)	1_6-1_15	10 / 20

Linkage	Site Range	Site Count
Phosporothioate	1_2-1_20	19 / 19

Related Record Type Details


					UU75G79NK3

AMLIVIRSEN

ACTIVE MOIETY

Comments:

antiviral

Structural Modifications

Modification Type	Location Site	Fragment Name	Fragment Approval
NUCLEOSIDE_SUBSTITUTION	[1_2] [1_20]	2'-O-(2-METHOXYETHYL)-5-METHYLCYTIDINE	AOQ54IZZ6J
NUCLEOTIDE SUBSTITUTION	[1_1]	AMLIVIRSEN 5' MODIFICATION	Z81G1Z99W2
NUCLEOSIDE_SUBSTITUTION	[1_3] [1_5] [1_16]	2'-O-(2-METHOXYETHYL)ADENOSINE	CPN45E0H91
NUCLEOSIDE_SUBSTITUTION	[1_18]	2'-O-(2-METHOXYETHYL)-5-METHYLURIDINE	9Q36I4D9VB
NUCLEOSIDE_SUBSTITUTION	[1_4] [1_17] [1_19]	2'-O-(2-METHOXYETHYL)GUANOSINE	509W6DE18G