BMS-275183

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C43H59NO16
Molecular Weight	845.9257
Optical Activity	UNSPECIFIED
Defined Stereocenters	11 / 11
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@]12[C@H](OC(=O)C3=CC=CC=C3)[C@]4(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C(C)(C)C)C(C)=C([C@@H](OC(C)=O)C(=O)[C@]1(C)[C@@H](O)C[C@H]5OC[C@@]25OC(=O)OC)C4(C)C

InChI

InChIKey=AHXICHPPXIGCBN-GPWPDEGDSA-N

InChI=1S/C43H59NO16/c1-21-24(57-35(50)28(47)31(38(3,4)5)44-36(51)59-39(6,7)8)19-43(53)33(58-34(49)23-16-14-13-15-17-23)30-41(11,32(48)29(56-22(2)45)27(21)40(43,9)10)25(46)18-26-42(30,20-55-26)60-37(52)54-12/h13-17,24-26,28-31,33,46-47,53H,18-20H2,1-12H3,(H,44,51)/t24-,25-,26+,28+,29+,30-,31+,33-,41+,42-,43+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C43H59NO16
Molecular Weight	845.9257
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	10 / 11
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/26146540 | https://adisinsight.springer.com/drugs/800016612

Bristol-Myers Squibb developed BMS-275183 for cancer indications. BMS 275183 is an inhibitor of tubulin polymerization. The drug participated in phase II clinical trials for patients with non-small cell lung cancer and in phase I for patients with advanced cancer. However, further development has been discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
Preclinical pharmacology of BMS-275183, an orally active taxane.	2001 Jul	11448919
The discovery of BMS-275183: an orally efficacious novel taxane.	2003 Oct 1	13129567
"Effect of the drug transporters ABCB1, ABCC2, and ABCG2 on the disposition and brain accumulation of the taxane analog BMS-275,183".	2014 Dec	25078948

Sample Use Guides

In Vivo Use Guide

BMS-275183 given orally twice weekly to patients pretreated for locally advanced or metastatic (Non Small Cell Lung Cancer) will show anti-tumor activity in any of the 3 separate cohorts of the patients enrolled

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:24:25 GMT 2023` Edited by `admin` on `Fri Dec 15 16:24:25 GMT 2023`
Record UNII	UQC681JJIV
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BMS-275183

Common Name

English

BMS 275183 [WHO-DD]

Common Name

English

BMS 275183

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1490