Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C43H59NO16 |
| Molecular Weight | 845.9257 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 11 / 11 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@]3(C)[C@@H]2[C@H](OC(=O)C4=CC=CC=C4)[C@]5(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C(C)(C)C)C(C)=C([C@@H](OC(C)=O)C3=O)C5(C)C
InChI
InChIKey=AHXICHPPXIGCBN-GPWPDEGDSA-N
InChI=1S/C43H59NO16/c1-21-24(57-35(50)28(47)31(38(3,4)5)44-36(51)59-39(6,7)8)19-43(53)33(58-34(49)23-16-14-13-15-17-23)30-41(11,32(48)29(56-22(2)45)27(21)40(43,9)10)25(46)18-26-42(30,20-55-26)60-37(52)54-12/h13-17,24-26,28-31,33,46-47,53H,18-20H2,1-12H3,(H,44,51)/t24-,25-,26+,28+,29+,30-,31+,33-,41+,42-,43+/m0/s1
| Molecular Formula | C43H59NO16 |
| Molecular Weight | 845.9257 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 11 / 11 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Bristol-Myers Squibb developed BMS-275183 for cancer indications. BMS 275183 is an inhibitor of tubulin polymerization. The drug participated in phase II clinical trials for patients with non-small cell lung cancer and in phase I for patients with advanced cancer. However, further development has been discontinued.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| "Effect of the drug transporters ABCB1, ABCC2, and ABCG2 on the disposition and brain accumulation of the taxane analog BMS-275,183". | 2014-12 |
|
| The discovery of BMS-275183: an orally efficacious novel taxane. | 2003-10-01 |
|
| Preclinical pharmacology of BMS-275183, an orally active taxane. | 2001-07 |
| Substance Class |
Chemical
Created
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Edited
Mon Mar 31 18:27:03 GMT 2025
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| Record UNII |
UQC681JJIV
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| Record Status |
Validated (UNII)
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C1490
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NCI_THESAURUS |
C67437
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UQC681JJIV
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DB12144
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300000042520
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6918594
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355113-98-3
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406911-32-8
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C62639
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DTXSID60193669
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ACTIVE MOIETY |
