INCLISIRAN SODIUM

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Sat Dec 16 18:56:43 GMT 2023` Edited by `admin` on `Sat Dec 16 18:56:43 GMT 2023`
Nucleic Acid Type	siRNA
Nucleic Acid Subtype
Sequence Origin	SYNTHETIC
Sequence Type	OLIGONUCLEOTIDE
Record UNII	UPC6BTX7PY
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

INCLISIRAN SODIUM

Common Name

English

RNA, (AM-SP-(2'-DEOXY-2'-FLUORO)C-SP-AM-(2'-DEOXY-2'-FLUORO)A-(2'-DEOXY-2'-FLUORO)A-(2'-DEOXY-2'-FLUORO)A-GM-(2'-DEOXY-2'-FLUORO)C-AM-(2'-DEOXY-2'-FLUORO)A-AM-(2'-DEOXY-2'-FLUORO)A-CM-(2'-DEOXY-2'-FLUORO)A-GM-(2'-DEOXY-2'-FLUORO)G-UM-(2'-DEOXY-2'-FLUORO)

Systematic Name

English

LEQVIO SODIUM

Brand Name

English

ALN-PCSSC SODIUM

Code

English

Inclisiran sodium [WHO-DD]

Common Name

English

ALN-60212 SODIUM

Code

English

INCLISIRAN SODIUM [JAN]

Common Name

English

Code System Code Type Description

SMS_ID

300000013624

Created by admin on Sat Dec 16 18:56:43 GMT 2023 , Edited by admin on Sat Dec 16 18:56:43 GMT 2023

PRIMARY

RXCUI

2588259

Created by admin on Sat Dec 16 18:56:43 GMT 2023 , Edited by admin on Sat Dec 16 18:56:43 GMT 2023

PRIMARY

DAILYMED

UPC6BTX7PY

Created by admin on Sat Dec 16 18:56:43 GMT 2023 , Edited by admin on Sat Dec 16 18:56:43 GMT 2023

PRIMARY

CAS

1639324-62-1

Created by admin on Sat Dec 16 18:56:43 GMT 2023 , Edited by admin on Sat Dec 16 18:56:43 GMT 2023

PRIMARY

FDA UNII

UPC6BTX7PY

Created by admin on Sat Dec 16 18:56:43 GMT 2023 , Edited by admin on Sat Dec 16 18:56:43 GMT 2023

PRIMARY

Sugar	Site Range	Site Count
Deoxyribose (DNA)	1_11	1 / 45
2'-Fluoro-Ribose	1_7;1_9;2_2;2_4-2_6;2_8;2_10;2_12;2_14;2_16;2_18	12 / 45
2'-O-Methyl-Ribose	1_1-1_6;1_8;1_10;1_12-1_22;2_1;2_3;2_7;2_9;2_11;2_13;2_15;2_17;2_19-2_23	32 / 45

Linkage	Site Range	Site Count
Sodium Phosporothioate	1_2-1_3;2_2-2_3;2_22-2_23	6 / 43
	1_1;1_4-1_21;2_1;2_4-2_20	37 / 43

Related Record Type Details


					UOW2C71PG5

PARENT -> SALT/SOLVATE

Amount:

Related Record Type Details


					UOW2C71PG5

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOTIDE SUBSTITUTION	[1_22]	SITE_SPECIFIC	U		GIVOSIRAN SODIUM TRIGLYCAN-END GROUP	8142CN1H73

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:SEQUNENCE(CALCULATED)	CHEMICAL