FLUNOXAPROFEN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C16H12FNO3
Molecular Weight	285.2698
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@H](C(O)=O)C1=CC2=C(OC(=N2)C3=CC=C(F)C=C3)C=C1

InChI

InChIKey=ARPYQKTVRGFPIS-VIFPVBQESA-N

InChI=1S/C16H12FNO3/c1-9(16(19)20)11-4-7-14-13(8-11)18-15(21-14)10-2-5-12(17)6-3-10/h2-9H,1H3,(H,19,20)/t9-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C16H12FNO3
Molecular Weight	285.2698
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2942383 | https://www.ncbi.nlm.nih.gov/pubmed/19786506 | Aronson, J.K. (2015) Meyler's Side Effects of Drugs, page 365, retrieved from: https://books.google.ru/books?id=NOKoBAAAQBAJ

Flunoxaprofen is a chiral nonsteroidal anti-inflammatory drug (NSAID). It is an arylalkanoic acid derivative. Flunoxaprofen inhibits leukotriene rather than prostaglandin synthesis. Its potency was comparable with that of indomethacin and higher than that of acetyl salicylic acid, ibuprofen or phenylbutazone. The analgesic activity of flunoxaprofen, evaluated by the hot plate method and tail pinching in mice, was slightly lower than that of indomethacin but higher than that of acetyl salicylic acid and ibuprofen. Its adverse reactions profile is similar to the profiles of other NSAIDs, including gastrointestinal disturbances. Flunoxaprofen was withdrawn from clinical use because of concerns of potential hepatotoxicity.

Approval Year

PubMed

Title	Date	PubMed
Interference of the new antiinflammatory compound flunoxaprofen with eicosanoid formation in various biological systems.	1987 Jan	3566853
Determination of the non-steroidal anti-inflammatory drug flunoxaprofen, S(+)-2-(4-fluorophenyl)-alpha-methyl-5-benzoxazoleacetic acid, in blood and urine by high-performance liquid chromatography.	1987 Jan 23	3558688

Sample Use Guides

In Vivo Use Guide

100 mg twice a day for a 60 days period

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:27:21 UTC 2023` Edited by `admin` on `Fri Dec 15 16:27:21 UTC 2023`
Record UNII	UKU5U19W9M
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FLUNOXAPROFEN

Official Name

English

Flunoxaprofen [WHO-DD]

Common Name

English

flunoxaprofen [INN]

Common Name

English

FLUNOXAPROFEN [MART.]

Common Name

English

(+)-2-(P-FLUOROPHENYL)-.ALPHA.-METHYL-5-BENZOXAZOLEACETIC ACID

Common Name

English

FLUNOXAPROFEN [MI]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QM01AE15