BROXYQUINOLINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H5Br2NO
Molecular Weight	302.95
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC1=C(Br)C=C(Br)C2=C1N=CC=C2

InChI

InChIKey=ZDASUJMDVPTNTF-UHFFFAOYSA-N

InChI=1S/C9H5Br2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H

HIDE SMILES / InChI

Molecular Formula	C9H5Br2NO
Molecular Weight	302.95
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.whocc.no/atc_ddd_index/?code=A07AX01&showdescription=yes | https://www.ncbi.nlm.nih.gov/pubmed/4792779 | https://www.ncbi.nlm.nih.gov/pubmed/22167242 | https://www.ncbi.nlm.nih.gov/pubmed/14224900 | https://www.ncbi.nlm.nih.gov/pubmed/14154276 | https://www.ncbi.nlm.nih.gov/pubmed/23207768

Broxyquinoline is an anti-infective agent. It exerts activity against fungi and protozoa. Broxyquinoline (Intestopan) has been used in the treatment of diarrhoeas of different aetiology. Broxyquinoline is able to promote neovascularization.

Approval Year

Targets

Primary Target	Pharmacology	Potency
UNIPROT: Q208C2 (Acyl-CoA-binding protein) 2 Target ID: UNIPROT: Q208C2 (Acyl-CoA-binding protein) Sources: https://www.ncbi.nlm.nih.gov/pubmed/22167242	Inhibitor 8297	64.9 µM [IC50]
Trichomonas vaginalis 11 Target ID: CHEMBL612884 Sources: https://www.ncbi.nlm.nih.gov/pubmed/102108	Inhibitor 8297
Candida albicans 14 Target ID: CHEMBL366 Sources: https://www.ncbi.nlm.nih.gov/pubmed/102108	Inhibitor 8297

PubMed

Title	Date	PubMed
THE IN VITRO EFFECT OF 8-HYDROXYQUINOLINE DERIVATIVES ON STRAINS OF MYCOBACTERIUM TUBERCULOSIS.	1964 Feb	14127303
A study on the neurotoxicity of broxyquinoline and brobenzoxaldine combination in therapeutic doses.	1986 Jan	3081428
A rapid spectrophotometric method for the determination of molybdenum in industrial, environmental, biological and soil samples using 5,7-dibromo-8-hydroxyquinoline.	2002 Apr	11999518
A simple spectrophotometric method for the determination of cadmium in industrial, environmental, biological and soil samples using 5,7-dibromo-8-hydroxyquinoline.	2004 Jun	15228125
Solid phase extraction vis-à-vis coprecipitation preconcentration of cadmium and lead from soils onto 5,7-dibromoquinoline-8-ol embedded benzophenone and determination by FAAS.	2006 Jun 15	18970661
The evaluation of liposome-water partitioning of 8-hydroxyquinolines and their copper complexes.	2006 Mar 15	16570598
Liquid phase microextraction and ultratrace determination of cadmium by modified graphite furnace atomic absorption spectrometry.	2009 Jun 15	19010596
2-[(5,7-Dibromo-quinolin-8-yl)-oxy]-N-(2-meth-oxy-phen-yl)acetamide.	2010 Nov 24	21589573

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:30:21 GMT 2023` Edited by `admin` on `Fri Dec 15 16:30:21 GMT 2023`
Record UNII	UK4C618C8T
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BROXYQUINOLINE

Official Name

English

BROXYQUINOLINE [MI]

Common Name

English

STAROGYN

Brand Name

English

5,7-DIBROMO-8-QUINOLINOL

Systematic Name

English

NSC-1810

Code

English

Broxyquinoline [WHO-DD]

Common Name

English

DIBROMOXIN

Systematic Name

English

broxyquinoline [INN]

Common Name

English

BROXYQUINOLINE [MART.]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C28394

Created by admin on Fri Dec 15 16:30:22 GMT 2023 , Edited by admin on Fri Dec 15 16:30:22 GMT 2023

WHO-ATC

P01AA01

Created by admin on Fri Dec 15 16:30:21 GMT 2023 , Edited by admin on Fri Dec 15 16:30:21 GMT 2023

WHO-VATC

QA07AX01

Created by admin on Fri Dec 15 16:30:22 GMT 2023 , Edited by admin on Fri Dec 15 16:30:22 GMT 2023

WHO-ATC

G01AC06

Created by admin on Fri Dec 15 16:30:21 GMT 2023 , Edited by admin on Fri Dec 15 16:30:21 GMT 2023

WHO-VATC

QG01AC06

Created by admin on Fri Dec 15 16:30:22 GMT 2023 , Edited by admin on Fri Dec 15 16:30:22 GMT 2023

WHO-ATC

A07AX01

Created by admin on Fri Dec 15 16:30:21 GMT 2023 , Edited by admin on Fri Dec 15 16:30:21 GMT 2023

Code System Code Type Description

EPA CompTox

DTXSID9045849

Created by admin on Fri Dec 15 16:30:21 GMT 2023 , Edited by admin on Fri Dec 15 16:30:21 GMT 2023

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FDA UNII

UK4C618C8T

Created by admin on Fri Dec 15 16:30:21 GMT 2023 , Edited by admin on Fri Dec 15 16:30:21 GMT 2023

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DRUG BANK

DB13536

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WIKIPEDIA

BROXYQUINOLINE

Created by admin on Fri Dec 15 16:30:22 GMT 2023 , Edited by admin on Fri Dec 15 16:30:22 GMT 2023

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MESH

C002276

Created by admin on Fri Dec 15 16:30:21 GMT 2023 , Edited by admin on Fri Dec 15 16:30:21 GMT 2023

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INN

1244

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EVMPD

SUB05940MIG

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PUBCHEM

2453

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SMS_ID

100000085842

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CAS

521-74-4

Created by admin on Fri Dec 15 16:30:21 GMT 2023 , Edited by admin on Fri Dec 15 16:30:21 GMT 2023

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NCI_THESAURUS

C73253

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MERCK INDEX

m2732

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Merck Index

DRUG CENTRAL

412

Created by admin on Fri Dec 15 16:30:21 GMT 2023 , Edited by admin on Fri Dec 15 16:30:21 GMT 2023

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ECHA (EC/EINECS)

208-317-8

Created by admin on Fri Dec 15 16:30:21 GMT 2023 , Edited by admin on Fri Dec 15 16:30:21 GMT 2023

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ChEMBL

CHEMBL223448

Created by admin on Fri Dec 15 16:30:21 GMT 2023 , Edited by admin on Fri Dec 15 16:30:21 GMT 2023

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NSC

1810

Created by admin on Fri Dec 15 16:30:22 GMT 2023 , Edited by admin on Fri Dec 15 16:30:22 GMT 2023

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Related Record Type Details


					UK4C618C8T

BROXYQUINOLINE

ACTIVE MOIETY