PEFORELIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C59H74N18O14
Molecular Weight	1259.3311
Optical Activity	UNSPECIFIED
Defined Stereocenters	9 / 9
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NCCCC[C@H](NC(=O)[C@H](CC1=CNC2=CC=CC=C12)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC3=CNC=N3)NC(=O)[C@H](CO)NC(=O)[C@H](CC4=CNC5=CC=CC=C45)NC(=O)[C@H](CC6=CNC=N6)NC(=O)[C@@H]7CCC(=O)N7)C(=O)N8CCC[C@H]8C(=O)NCC(N)=O

InChI

InChIKey=RTASYRSYWSLWJV-CSYZDTNESA-N

InChI=1S/C59H74N18O14/c60-16-6-5-12-40(59(91)77-17-7-13-47(77)58(90)66-27-48(61)79)70-52(84)41(18-31-23-64-37-10-3-1-8-35(31)37)72-56(88)45(22-50(81)82)75-55(87)44(21-34-26-63-30-68-34)74-57(89)46(28-78)76-53(85)42(19-32-24-65-38-11-4-2-9-36(32)38)71-54(86)43(20-33-25-62-29-67-33)73-51(83)39-14-15-49(80)69-39/h1-4,8-11,23-26,29-30,39-47,64-65,78H,5-7,12-22,27-28,60H2,(H2,61,79)(H,62,67)(H,63,68)(H,66,90)(H,69,80)(H,70,84)(H,71,86)(H,72,88)(H,73,83)(H,74,89)(H,75,87)(H,76,85)(H,81,82)/t39-,40-,41-,42-,43-,44-,45-,46-,47-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C59H74N18O14
Molecular Weight	1259.3311
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	9 / 9
E/Z Centers	4
Optical Activity	UNSPECIFIED

Description
Sources: http://www.sgau.ru/files/pages/846/14713368000.pdf#page=48 | https://www.ema.europa.eu/en/documents/mrl-report/peforelin-summary-report-cvmp-establishment-maximum-residue-limits_en.pdf

Peforelin, a decapeptide analog of the natural gonadotropin acts as the natural gonadotropin-releasing hormone (GnRH) agonist. This drug under the brand name Maprelin is used in veterinary to stimulate the reproductive function of sows after weaning piglets in the syndrome of sexual depression.

Approval Year

PubMed

Title	Date	PubMed
Influence of synthetic lamprey GnRH-III on gonadotropin release and steroid hormone levels in gilts.	2010 Dec	20708243
Effect of a GnRH analogue (Maprelin) on the reproductive performance of gilts and sows.	2013 Nov	23987986
Effect of a GnRH analogue (peforelin) on the litter performance of gilts and sows.	2017	28405462

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:49:31 UTC 2023` Edited by `admin` on `Fri Dec 15 15:49:31 UTC 2023`
Record UNII	UJ8NQ5Z0VX
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PEFORELIN

Official Name

English

GLYCINAMIDE, 5-OXO-L-PROLYL-L-HISTIDYL-L-TRYPTOPHYL-L-SERYL-L-HISTIDYL-L-.ALPHA.-ASPARTYL-L-TRYPTOPHYL-L-LYSYL-L-PROLYL-

Systematic Name

English

PGLU-HIS-TRP-SER-HIS-ASP-TRP-LYS-PRO-GLY-NH2

Common Name

English

PYROGLU-HIS-TRP-SER-HIS-ASP-TRP-LYS-PRO-GLY-NH2

Common Name

English

LAMPREY LH-RH III

Common Name

English

LUTEINIZING HORMONE-RELEASING FACTOR III (PETROMYZON MARINUS)

Common Name

English

MAPRELIN XP10

Common Name

English

LAMPREY GONADOTROPIN-RELEASING HORMONE-III

Common Name

English

peforelin [INN]

Common Name

English

GNRH III

Common Name

English

PEFORELIN [MI]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QH01CA95