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Details

Stereochemistry RACEMIC
Molecular Formula C27H34N4O10
Molecular Weight 574.5797
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of RAZINODIL

SMILES

COC1=CC(=CC(OC)=C1OC)C(=O)OC(CN2CCOCC2)CN3N=NC4=C(OC)C(OC)=C(OC)C=C4C3=O

InChI

InChIKey=KUUKBTYSAHIXTN-UHFFFAOYSA-N
InChI=1S/C27H34N4O10/c1-34-19-11-16(12-20(35-2)23(19)37-4)27(33)41-17(14-30-7-9-40-10-8-30)15-31-26(32)18-13-21(36-3)24(38-5)25(39-6)22(18)28-29-31/h11-13,17H,7-10,14-15H2,1-6H3

HIDE SMILES / InChI

Molecular Formula C27H34N4O10
Molecular Weight 574.5797
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description

Razinodil was developed as a coronary vasodilator, a drug that reduces blood pressure by dilating blood vessels. It was tested for its potential as a drug in ischemic myocardial diseases. In a canine heart-lung laboratory model, it increased coronary blood flow without increasing oxygen consumption. Only slight negative chronotropic (heart rate) and inotropic (cardiac contraction) effects were reported. Razinodil also improved the survival rate of miniature pigs after an induced heart attack.

Approval Year

Substance Class Chemical
Created
by admin
on Fri Dec 15 16:01:48 GMT 2023
Edited
by admin
on Fri Dec 15 16:01:48 GMT 2023
Record UNII
UJ1O5LVT0G
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
RAZINODIL
INN  
INN  
Official Name English
razinodil [INN]
Common Name English
NSC-310409
Code English
Classification Tree Code System Code
NCI_THESAURUS C29707
Created by admin on Fri Dec 15 16:01:48 GMT 2023 , Edited by admin on Fri Dec 15 16:01:48 GMT 2023
Code System Code Type Description
EVMPD
SUB10264MIG
Created by admin on Fri Dec 15 16:01:48 GMT 2023 , Edited by admin on Fri Dec 15 16:01:48 GMT 2023
PRIMARY
PUBCHEM
65771
Created by admin on Fri Dec 15 16:01:48 GMT 2023 , Edited by admin on Fri Dec 15 16:01:48 GMT 2023
PRIMARY
ChEMBL
CHEMBL2104773
Created by admin on Fri Dec 15 16:01:48 GMT 2023 , Edited by admin on Fri Dec 15 16:01:48 GMT 2023
PRIMARY
NSC
310409
Created by admin on Fri Dec 15 16:01:48 GMT 2023 , Edited by admin on Fri Dec 15 16:01:48 GMT 2023
PRIMARY
SMS_ID
100000080821
Created by admin on Fri Dec 15 16:01:48 GMT 2023 , Edited by admin on Fri Dec 15 16:01:48 GMT 2023
PRIMARY
NCI_THESAURUS
C77078
Created by admin on Fri Dec 15 16:01:48 GMT 2023 , Edited by admin on Fri Dec 15 16:01:48 GMT 2023
PRIMARY
INN
4294
Created by admin on Fri Dec 15 16:01:48 GMT 2023 , Edited by admin on Fri Dec 15 16:01:48 GMT 2023
PRIMARY
MESH
C031048
Created by admin on Fri Dec 15 16:01:48 GMT 2023 , Edited by admin on Fri Dec 15 16:01:48 GMT 2023
PRIMARY
EPA CompTox
DTXSID40865534
Created by admin on Fri Dec 15 16:01:48 GMT 2023 , Edited by admin on Fri Dec 15 16:01:48 GMT 2023
PRIMARY
FDA UNII
UJ1O5LVT0G
Created by admin on Fri Dec 15 16:01:48 GMT 2023 , Edited by admin on Fri Dec 15 16:01:48 GMT 2023
PRIMARY
CAS
30271-85-3
Created by admin on Fri Dec 15 16:01:48 GMT 2023 , Edited by admin on Fri Dec 15 16:01:48 GMT 2023
PRIMARY
Related Record Type Details
ENANTIOMER -> RACEMATE
ENANTIOMER -> RACEMATE
Related Record Type Details
ACTIVE MOIETY