Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C20H34O4 |
| Molecular Weight | 338.4816 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCC[C@H](O)\C=C\[C@H]1CCC(=O)[C@@H]1CCCCCCC(O)=O
InChI
InChIKey=DPNOTBLPQOITGU-LDDQNKHRSA-N
InChI=1S/C20H34O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,16-18,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t16-,17-,18+/m0/s1
| Molecular Formula | C20H34O4 |
| Molecular Weight | 338.4816 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 1 |
| Optical Activity | UNSPECIFIED |
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: P43116 Gene ID: 5732.0 Gene Symbol: PTGER2 Target Organism: Homo sapiens (Human) |
45.0 nM [Ki] | ||
Target ID: P35408 Gene ID: 5734.0 Gene Symbol: PTGER4 Target Organism: Homo sapiens (Human) |
23.0 nM [Ki] | ||
Target ID: P43115|||Q16546 Gene ID: 5733.0 Gene Symbol: PTGER3 Target Organism: Homo sapiens (Human) |
1.5 nM [Ki] |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
PubMed
| Title | Date | PubMed |
|---|---|---|
| Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes. | 1997 Dec 11 |
|
| Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. | 1997 Sep |
|
| Characterization of the prostanoid receptor(s) on human blood monocytes at which prostaglandin E2 inhibits lipopolysaccharide-induced tumour necrosis factor-alpha generation. | 1997 Sep |
|
| Pharmacological characterization of [(3)H]-prostaglandin E(2) binding to the cloned human EP(4) prostanoid receptor. | 2000 Aug |
Patents
Sample Use Guides
In Vitro Use Guide
Curator's Comment: The addition of 11-deoxy-PGE1 (EP4 receptor agonist) to rat renal epithelial cell line (NRK-52E) increased the cell number, indicating the effects of PGE2 via EP4 receptor. Furthermore, 11-deoxy-PGE1-treated NRK-52E cells underwent the G0/G1 arrest and decreased apoptosis. NRK-52E treated with transforming growth factor (TGF)-beta1, an inducer of epithelial-mesenchymal transition (EMT), in the presence of 11-deoxy-PGE1 decreased the mRNA expression of alpha-smooth muscle actin (a marker of myofibroblasts).
Unknown
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 17:59:22 GMT 2023
by
admin
on
Fri Dec 15 17:59:22 GMT 2023
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| Record UNII |
UG6237D2HO
|
| Record Status |
Validated (UNII)
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| Record Version |
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5283055
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UG6237D2HO
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DTXSID101317623
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C034008
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37786-00-8
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