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Details

Stereochemistry ACHIRAL
Molecular Formula C21H23NO3
Molecular Weight 337.4122
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PARGEVERINE

SMILES

CN(C)CCOC(=O)C(OCC#C)(C1=CC=CC=C1)C2=CC=CC=C2

InChI

InChIKey=QNPHCSSJLHAKSA-UHFFFAOYSA-N
InChI=1S/C21H23NO3/c1-4-16-25-21(18-11-7-5-8-12-18,19-13-9-6-10-14-19)20(23)24-17-15-22(2)3/h1,5-14H,15-17H2,2-3H3

HIDE SMILES / InChI

Molecular Formula C21H23NO3
Molecular Weight 337.4122
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Pargeverine (also known as a propinox) is an antispasmodic drug that was studied for the treatment of disorders of the gastrointestinal tract, the uterus, and the gallbladder. Pargeverine showed a dual mechanism of action, it binds to muscarinic and calcium receptors that can be related to its antispasmodic activity. The clinical trial has shown that pargeverine was an effective drug in the treatment of moderate to severe colic pain of biliary origin. In addition, its efficacy and tolerability were determined in patients with moderate-to-severe acute intestinal colic pain. As a result, no differences in blood pressure or heart rate were found among treatments. The incidence of mouth dryness was significantly more frequent with the 20 mg and 30 mg doses of propinox than with the placebo or the 10 mg dose. Information about the current development of this drug is not available.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
1.2 µM [Ki]
100.0 µM [Ki]
1.5 µM [Ki]
PubMed

PubMed

TitleDatePubMed
Determination of the melanotropin-inhibiting factor analogue pareptide in urine by high-performance liquid chromatography.
1981 Mar 13
Antispasmodic/analgesic associations in primary dysmenorrhea double-blind crossover placebo-controlled clinical trial.
2001

Sample Use Guides

propinox (PARGEVERINE) administered i.v. (10 mg, 20 mg and 30 mg)
Route of Administration: Intravenous
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:37:26 GMT 2023
Edited
by admin
on Fri Dec 15 16:37:26 GMT 2023
Record UNII
UC61HM8FX0
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PARGEVERINE
INN   WHO-DD  
INN  
Official Name English
PARGEVERIN
Common Name English
Pargeverine [WHO-DD]
Common Name English
VIADIL
Brand Name English
PROPINOX
Common Name English
pargeverine [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29698
Created by admin on Fri Dec 15 16:37:26 GMT 2023 , Edited by admin on Fri Dec 15 16:37:26 GMT 2023
Code System Code Type Description
CAS
13479-13-5
Created by admin on Fri Dec 15 16:37:26 GMT 2023 , Edited by admin on Fri Dec 15 16:37:26 GMT 2023
PRIMARY
FDA UNII
UC61HM8FX0
Created by admin on Fri Dec 15 16:37:26 GMT 2023 , Edited by admin on Fri Dec 15 16:37:26 GMT 2023
PRIMARY
INN
4389
Created by admin on Fri Dec 15 16:37:26 GMT 2023 , Edited by admin on Fri Dec 15 16:37:26 GMT 2023
PRIMARY
MESH
C087283
Created by admin on Fri Dec 15 16:37:26 GMT 2023 , Edited by admin on Fri Dec 15 16:37:26 GMT 2023
PRIMARY
SMS_ID
100000078747
Created by admin on Fri Dec 15 16:37:26 GMT 2023 , Edited by admin on Fri Dec 15 16:37:26 GMT 2023
PRIMARY
EPA CompTox
DTXSID1048386
Created by admin on Fri Dec 15 16:37:26 GMT 2023 , Edited by admin on Fri Dec 15 16:37:26 GMT 2023
PRIMARY
NCI_THESAURUS
C66320
Created by admin on Fri Dec 15 16:37:26 GMT 2023 , Edited by admin on Fri Dec 15 16:37:26 GMT 2023
PRIMARY
RXCUI
76273
Created by admin on Fri Dec 15 16:37:26 GMT 2023 , Edited by admin on Fri Dec 15 16:37:26 GMT 2023
PRIMARY RxNorm
PUBCHEM
17700
Created by admin on Fri Dec 15 16:37:26 GMT 2023 , Edited by admin on Fri Dec 15 16:37:26 GMT 2023
PRIMARY
DRUG CENTRAL
2064
Created by admin on Fri Dec 15 16:37:26 GMT 2023 , Edited by admin on Fri Dec 15 16:37:26 GMT 2023
PRIMARY
EVMPD
SUB12425MIG
Created by admin on Fri Dec 15 16:37:26 GMT 2023 , Edited by admin on Fri Dec 15 16:37:26 GMT 2023
PRIMARY
ChEMBL
CHEMBL1872101
Created by admin on Fri Dec 15 16:37:26 GMT 2023 , Edited by admin on Fri Dec 15 16:37:26 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY