Details
Stereochemistry | ACHIRAL |
Molecular Formula | C6H7AsNO3.Na |
Molecular Weight | 239.036 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].NC1=CC=C(C=C1)[As](O)([O-])=O
InChI
InChIKey=OUFRIWNNMFWZTM-UHFFFAOYSA-M
InChI=1S/C6H8AsNO3.Na/c8-6-3-1-5(2-4-6)7(9,10)11;/h1-4H,8H2,(H2,9,10,11);/q;+1/p-1
Molecular Formula | C6H7AsNO3 |
Molecular Weight | 216.0463 |
Charge | -1 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | Na |
Molecular Weight | 22.9898 |
Charge | 1 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: http://www.who.int/trypanosomiasis_african/country/history/en/index6.html | https://www.ncbi.nlm.nih.gov/pubmed/24251577 | https://www.ncbi.nlm.nih.gov/pubmed/920189 | https://www.ncbi.nlm.nih.gov/pubmed/3742372https://www.ncbi.nlm.nih.gov/pubmed/24136205Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/20763444 | https://www.ncbi.nlm.nih.gov/pubmed/21772505 | https://www.ncbi.nlm.nih.gov/pubmed/20219092
Sources: http://www.who.int/trypanosomiasis_african/country/history/en/index6.html | https://www.ncbi.nlm.nih.gov/pubmed/24251577 | https://www.ncbi.nlm.nih.gov/pubmed/920189 | https://www.ncbi.nlm.nih.gov/pubmed/3742372https://www.ncbi.nlm.nih.gov/pubmed/24136205
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/20763444 | https://www.ncbi.nlm.nih.gov/pubmed/21772505 | https://www.ncbi.nlm.nih.gov/pubmed/20219092
Arsanilic acid, also known as aminophenyl arsenic acid or aminophenyl arsonic acid, is an organoarsenic compound first reported in 1863 by Antoine Béchamp. Arsanilic acid is a crystalline powder introduced medically in the late 19th century as Atoxyl, its sodium salt was used by injection in the early 20th century as the first organic arsenical drug, but it was soon found prohibitively toxic for human use. Arsanilic acid saw long use as a veterinary feed additive promoting growth and to prevent or treat dysentery in poultry and swine. In 2013, its approval by US government as an animal drug was voluntarily withdrawn by its sponsors. Still sometimes used in laboratories, Arsanilic acid's legacy is principally through its influence on Paul Ehrlich in launching the chemotherapeutic approach to treating infectious diseases of humans.
Originator
Sources: http://www.who.int/trypanosomiasis_african/country/history/en/index6.html | https://www.ncbi.nlm.nih.gov/pubmed/16103665M. A. Bechamp (1863). Compt. Rend. 56: 1172–1175.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: Treponema pallidum Sources: https://www.ncbi.nlm.nih.gov/pubmed/19868094 |
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Target ID: WP1018 Sources: https://www.ncbi.nlm.nih.gov/pubmed/23848144 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Atoxyl Approved UseAfrican trypanosomiasis |
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Primary | Atoxyl Approved UseSyphilis |
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Curative | Atoxyl Approved UseUnknown |
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Primary | Atoxyl Approved UseUnknown |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4272953
Pigs: 161 mg/liter in drinking water for seven days
Route of Administration:
Oral
In Vitro Use Guide
Sources: http://www.innovativesolution.it/atoxyl.htm
In cultures of retina in vitro, addition of 5X10-3 M sodium arsanilate has caused degeneration of the rod cells
Substance Class |
Chemical
Created
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admin
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Fri Dec 15 15:08:00 GMT 2023
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Fri Dec 15 15:08:00 GMT 2023
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Record UNII |
UC2409302Q
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Record Status |
Validated (UNII)
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Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE | |||
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SOLVATE->ANHYDROUS |