U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C6H7AsNO3.Na.4H2O
Molecular Weight 311.0972
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SODIUM ARSANILATE TETRAHYDRATE

SMILES

O.O.O.O.[Na+].NC1=CC=C(C=C1)[As](O)([O-])=O

InChI

InChIKey=IQHDBXORJXXEFF-UHFFFAOYSA-M
InChI=1S/C6H8AsNO3.Na.4H2O/c8-6-3-1-5(2-4-6)7(9,10)11;;;;;/h1-4H,8H2,(H2,9,10,11);;4*1H2/q;+1;;;;/p-1

HIDE SMILES / InChI

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C6H8AsNO3
Molecular Weight 217.0542
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/20763444 | https://www.ncbi.nlm.nih.gov/pubmed/21772505 | https://www.ncbi.nlm.nih.gov/pubmed/20219092

Arsanilic acid, also known as aminophenyl arsenic acid or aminophenyl arsonic acid, is an organoarsenic compound first reported in 1863 by Antoine Béchamp. Arsanilic acid is a crystalline powder introduced medically in the late 19th century as Atoxyl, its sodium salt was used by injection in the early 20th century as the first organic arsenical drug, but it was soon found prohibitively toxic for human use. Arsanilic acid saw long use as a veterinary feed additive promoting growth and to prevent or treat dysentery in poultry and swine. In 2013, its approval by US government as an animal drug was voluntarily withdrawn by its sponsors. Still sometimes used in laboratories, Arsanilic acid's legacy is principally through its influence on Paul Ehrlich in launching the chemotherapeutic approach to treating infectious diseases of humans.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

PubMed

PubMed

TitleDatePubMed
Efficacy of 101 antimicrobials and other agents on the development of Cryptosporidium parvum in vitro.
1996 Dec
The coordination complex structures and hydrogen bonding in the three-dimensional alkaline earth metal salts (Mg, Ca, Sr and Ba) of (4-aminophenyl)arsonic acid.
2017 Jan 1
Patents

Sample Use Guides

Pigs: 161 mg/liter in drinking water for seven days
Route of Administration: Oral
In Vitro Use Guide
In cultures of retina in vitro, addition of 5X10-3 M sodium arsanilate has caused degeneration of the rod cells
Substance Class Chemical
Created
by admin
on Sat Dec 16 08:21:35 GMT 2023
Edited
by admin
on Sat Dec 16 08:21:35 GMT 2023
Record UNII
TFX0FRW3R1
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SODIUM ARSANILATE TETRAHYDRATE
Common Name English
ARSONIC ACID, (4-AMINOPHENYL)-, MONOSODIUM SALT, TETRAHYDRATE
Systematic Name English
ARSANILIC ACID, MONOSODIUM SALT, TETRAHYDRATE
Common Name English
AS-(4-AMINOPHENYL)ARSONIC ACID SODIUM SALT TETRAHYDRATE
MI  
Systematic Name English
AS-(4-AMINOPHENYL)ARSONIC ACID SODIUM SALT TETRAHYDRATE [MI]
Common Name English
Code System Code Type Description
FDA UNII
TFX0FRW3R1
Created by admin on Sat Dec 16 08:21:35 GMT 2023 , Edited by admin on Sat Dec 16 08:21:35 GMT 2023
PRIMARY
CAS
6696-54-4
Created by admin on Sat Dec 16 08:21:35 GMT 2023 , Edited by admin on Sat Dec 16 08:21:35 GMT 2023
PRIMARY
PUBCHEM
23719536
Created by admin on Sat Dec 16 08:21:35 GMT 2023 , Edited by admin on Sat Dec 16 08:21:35 GMT 2023
PRIMARY
EPA CompTox
DTXSID90217160
Created by admin on Sat Dec 16 08:21:35 GMT 2023 , Edited by admin on Sat Dec 16 08:21:35 GMT 2023
PRIMARY
Related Record Type Details
ANHYDROUS->SOLVATE