GSK-945237

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C24H26FN5O3
Molecular Weight	451.4933
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC1=C2[C@H](CN3CCC(CC3)NCC4=CC5=C(OCCO5)N=N4)CN6C2=C(C=CC6=O)C=C1

InChI

InChIKey=SRICOHRDRMZREQ-MRXNPFEDSA-N

InChI=1S/C24H26FN5O3/c25-19-3-1-15-2-4-21(31)30-14-16(22(19)23(15)30)13-29-7-5-17(6-8-29)26-12-18-11-20-24(28-27-18)33-10-9-32-20/h1-4,11,16-17,26H,5-10,12-14H2/t16-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C24H26FN5O3
Molecular Weight	451.4933
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 07:09:54 GMT 2023` Edited by `admin` on `Sat Dec 16 07:09:54 GMT 2023`
Record UNII	U9T63BZ3AS
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

GSK-945237

Common Name

English

(1R)-1-((4-(((6,7-DIHYDRO(1,4)DIOXINO(2,3-C)PYRIDAZIN-3-YL)METHYL)AMINO)-1-PIPERIDINYL)METHYL)-9-FLUORO-1,2-DIHYDRO-4H-PYRROLO(3,2,1-IJ)QUINOLIN-4-ONE

Systematic Name

English

GSK945237

Code

English

945237

Code

English

4H-PYRROLO(3,2,1-IJ)QUINOLIN-4-ONE, 1-((4-(((6,7-DIHYDRO(1,4)DIOXINO(2,3-C)PYRIDAZIN-3-YL)METHYL)AMINO)-1-PIPERIDINYL)METHYL)-9-FLUORO-1,2-DIHYDRO-, (1R)-

Systematic Name

English

Code System Code Type Description

DRUG BANK

DB15345

Created by admin on Sat Dec 16 07:09:54 GMT 2023 , Edited by admin on Sat Dec 16 07:09:54 GMT 2023

PRIMARY

FDA UNII

U9T63BZ3AS

Created by admin on Sat Dec 16 07:09:54 GMT 2023 , Edited by admin on Sat Dec 16 07:09:54 GMT 2023

PRIMARY

CAS

944406-54-6

Created by admin on Sat Dec 16 07:09:54 GMT 2023 , Edited by admin on Sat Dec 16 07:09:54 GMT 2023

PRIMARY

PUBCHEM

119057475

Created by admin on Sat Dec 16 07:09:54 GMT 2023 , Edited by admin on Sat Dec 16 07:09:54 GMT 2023

PRIMARY

Related Record Type Details


					U9T63BZ3AS

GSK-945237

ACTIVE MOIETY

Comments:

MIC H. influenzae/S. aureus/S. pneumoniae13 (.MU.g/mL) = 1, 0.06, 0.25


					U9T63BZ3AS

GSK-945237

ACTIVE MOIETY

Comments:

H. influenzae DNA gyrase-dependent DNA replication IC5010 (.MU.g/mL) = 0.034

Amount:


					U9T63BZ3AS

GSK-945237

ACTIVE MOIETY

Comments:

Originator: GlaxoSmithKline Class: Antibacterial Mechanism of Action: Ribosomal protein inhibitor, Type II DNA topoisomerase inhibitor Highest Development Phase: Discontinued for Bacterial infections Most Recent Event: 13 May 2011 Discontinued for Phase-I for Bacterial infections in Australia (PO)