LY-518674

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C23H27N3O4
Molecular Weight	409.4782
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CC=C(CN2N=C(CCCC3=CC=C(OC(C)(C)C(O)=O)C=C3)NC2=O)C=C1

InChI

InChIKey=PNHFDVSKDSLUFH-UHFFFAOYSA-N

InChI=1S/C23H27N3O4/c1-16-7-9-18(10-8-16)15-26-22(29)24-20(25-26)6-4-5-17-11-13-19(14-12-17)30-23(2,3)21(27)28/h7-14H,4-6,15H2,1-3H3,(H,27,28)(H,24,25,29)

HIDE SMILES / InChI

Molecular Formula	C23H27N3O4
Molecular Weight	409.4782
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14613314 | https://www.ncbi.nlm.nih.gov/pubmed/15933217 | https://adisinsight.springer.com/drugs/800018151

LY-518674 is a highly potent and selective proliferator-activated receptor (PPAR)-alpha agonist. LY-518674 produced a much greater increase in serum high-density lipoprotein-cholesterol (HDL-c) than the known fibrate drugs. The increase in HDL-c was associated with de novo synthesis of apolipoprotein A-1. It was being developed for the treatment of dyslipidemias with atherogenic potential.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Peroxisome proliferator-activated receptor alpha 62 Target ID: Q07869 Gene ID: 5465.0 Gene Symbol: PPARA Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/14613314	Agonist 2678

PubMed

Title	Date	PubMed
Design and synthesis of a potent and selective triazolone-based peroxisome proliferator-activated receptor alpha agonist.	2003 Nov 20	14613314
On the mechanism for PPAR agonists to enhance ABCA1 gene expression.	2009 Aug	19201410

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:14:26 GMT 2023` Edited by `admin` on `Fri Dec 15 16:14:26 GMT 2023`
Record UNII	U8I57RC739
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LY-518674

Common Name

English

LY-674

Code

English

KB-68984

Code

English

PROPANOIC ACID, 2-(4-(3-(2,5-DIHYDRO-1-((4-METHYLPHENYL)METHYL)-5-OXO-1H-1,2,4-TRIAZOL-3-YL)PROPYL)PHENOXY)-2-METHYL-

Systematic Name

English

LY518674

Code

English

Code System Code Type Description

CAS

425671-29-0