Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C23H27N3O4 |
| Molecular Weight | 409.4782 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=CC=C(CN2N=C(CCCC3=CC=C(OC(C)(C)C(O)=O)C=C3)NC2=O)C=C1
InChI
InChIKey=PNHFDVSKDSLUFH-UHFFFAOYSA-N
InChI=1S/C23H27N3O4/c1-16-7-9-18(10-8-16)15-26-22(29)24-20(25-26)6-4-5-17-11-13-19(14-12-17)30-23(2,3)21(27)28/h7-14H,4-6,15H2,1-3H3,(H,27,28)(H,24,25,29)
| Molecular Formula | C23H27N3O4 |
| Molecular Weight | 409.4782 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
LY-518674 is a highly potent and selective proliferator-activated receptor (PPAR)-alpha agonist. LY-518674 produced a much greater increase in serum high-density lipoprotein-cholesterol (HDL-c) than the known fibrate drugs. The increase in HDL-c was associated with de novo synthesis of apolipoprotein A-1. It was being developed for the treatment of dyslipidemias with atherogenic potential.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| On the mechanism for PPAR agonists to enhance ABCA1 gene expression. | 2009-08 |
|
| Identification of a novel selective peroxisome proliferator-activated receptor alpha agonist, 2-methyl-2-(4-{3-[1-(4-methylbenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl]propyl}phenoxy)propanoic acid (LY518674), that produces marked changes in serum lipids and apolipoprotein A-1 expression. | 2005-09 |
|
| Design and synthesis of a potent and selective triazolone-based peroxisome proliferator-activated receptor alpha agonist. | 2003-11-20 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:22:48 GMT 2025
by
admin
on
Mon Mar 31 18:22:48 GMT 2025
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| Record UNII |
U8I57RC739
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| Record Status |
Validated (UNII)
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| Record Version |
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425671-29-0
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CHEMBL424133
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135449333
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U8I57RC739
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DB12988
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DTXSID10962564
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admin on Mon Mar 31 18:22:48 GMT 2025 , Edited by admin on Mon Mar 31 18:22:48 GMT 2025
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| Related Record | Type | Details | ||
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