DIMYRISTOYLPHOSPHATIDYLCHOLINE, DL-

Details

Stereochemistry	RACEMIC
Molecular Formula	C36H72NO8P
Molecular Weight	677.9325
Optical Activity	( + / - )
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of DIMYRISTOYLPHOSPHATIDYLCHOLINE, DL-

Structure Search

SMILES

CCCCCCCCCCCCCC(=O)OCC(COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCC

InChI

InChIKey=CITHEXJVPOWHKC-UHFFFAOYSA-N

InChI=1S/C36H72NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-35(38)42-32-34(33-44-46(40,41)43-31-30-37(3,4)5)45-36(39)29-27-25-23-21-19-17-15-13-11-9-7-2/h34H,6-33H2,1-5H3

HIDE SMILES / InChI

Molecular Formula	C36H72NO8P
Molecular Weight	677.9325
Charge	0
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 2
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: DOI: 10.1042/bst0170713
Curator's Comment: description was created based on several sources, including: http://www.wikidoc.org/index.php/Phosphatidylcholine http://www.ncbi.nlm.nih.gov/pubmed/4351059 http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm070570.pdf

DMPC belongs to the synthetic phosphatidylcholines. Phosphatidylcholines are a class of phospholipids that incorporate choline as a headgroup. DMPC is applied in lipid bilayer studies and in biological systems. Synthetic dimyristoylphosphatidylcholine liposomes are used in various ways as safe drug carriers.

Approval Year

Conditions

Condition	Modality	Highest Phase	Product
Choroidal neovascularization 2 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021119s027lbl.pdf	Inactive ingredient	Approved 8583	VISUDYNE Approved Use VISUDYNE for injection is a photosensitizer indicated for the treatment of patients with predominantly classic subfoveal choroidal neovascularization due to age-related macular degeneration, pathologic myopia or presumed ocular histoplasmosis. Launch Date 2000
Atherosclerosis 76 Sources: http://www.ncbi.nlm.nih.gov/pubmed/20876082	Primary	Preclinical	Unknown Approved Use Unknown
B-cell lymphoma 3 Sources: http://www.ncbi.nlm.nih.gov/pubmed/21619525	Primary	Preclinical	Unknown Approved Use Unknown
Lung cancer 70 Sources: http://www.ncbi.nlm.nih.gov/pubmed/10513636 http://www.ncbi.nlm.nih.gov/pubmed/21619525	Primary	Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Interaction of plasma high density lipoprotein HDL2b (d 1.063-1.100 g/ml) with single-bilayer liposomes of dimyristoylphosphatidylcholine.	1978-12	220490
Physical properties of the dimyristoylphosphatidylcholine vesicle and of complexes formed by its interaction with apolipoprotein C-III.	1977-05-17	193554
Phase separations in phospholipd membranes.	1975-02-25	163646

Patents

Sample Use Guides

In Vivo Use Guide

678 mg/kg were administrated once each day for 13 days

Route of Administration: Intraperitoneal

In Vitro Use Guide

IC50 of DMPC on the growth of B16 melanoma cells is about 0,5 mM.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:29:44 GMT 2025` Edited by `admin` on `Mon Mar 31 19:29:44 GMT 2025`
Record UNII	U86ZGC74V5
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DIMYRISTOYLPHOSPHATIDYLCHOLINE, DL-

Common Name

English

1,2-DIMYRISTOYL-DL-PHOSPHATIDYLCHOLINE

Preferred Name

English

3,5,9-TRIOXA-4-PHOSPHATRICOSAN-1-AMINIUM, 4-HYDROXY-N,N,N-TRIMETHYL-10-OXO-7-((1-OXOTETRADECYL)OXY)-, INNER SALT, 4-OXIDE

Common Name

English

DMPC

Common Name

English

DIMYRISTOYL-.ALPHA.-LECITHIN

Common Name

English

DIMYRISTOYL PHOSPHATIDYLCHOLINE, (±)-

Common Name

English

1,2-DIMYRISTOYL-PHOSPHATIDYLCHOLINE

Common Name

English

ALF component DMPC

Common Name

English

1,2-DIMYRISTOYL-GLYCERO-3-PHOSPHOCHOLINE, DL-

Common Name

English

1,2-DIMYRISTOYL-GLYCERO-3-PHOSPHOCHOLINE

Common Name

English

1,2-DIMYRISTOYL-PHOSPHATIDYLCHOLINE, (±)-

Common Name

English

DIMYRISTOYL PHOSPHATIDYLCHOLINE

Common Name

English

1,2-DIMYRISTOYL-GLYCERO-3-PHOSPHOCHOLINE, (±)-

Common Name

English

ALFQ component DMPC

Common Name

English

Army Liposome Formulation component DMPC

Common Name

English

DIMYRISTOYLPHOSPHATIDYLCHOLINE

Common Name

English

Code System Code Type Description

CHEBI

241349