Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Thu Jul 06 19:32:27 UTC 2023
by
admin
on
Thu Jul 06 19:32:27 UTC 2023
|
| Protein Type | ENZYME |
| Protein Sub Type | SERINE/THREONINE-PROTEIN KINASE |
| Sequence Origin | HUMAN |
| Sequence Type | COMPLETE |
| Record UNII |
U7FKT8J0J3
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
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Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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P15056
Created by
admin on Thu Jul 06 19:32:28 UTC 2023 , Edited by admin on Thu Jul 06 19:32:28 UTC 2023
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PRIMARY | |||
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U7FKT8J0J3
Created by
admin on Thu Jul 06 19:32:28 UTC 2023 , Edited by admin on Thu Jul 06 19:32:28 UTC 2023
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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INHIBITOR -> TARGET |
In contrast to approved therapies targeting Class I V600E BRAF mutant tumors, KIN-2787 was active across all classes of BRAF-altered melanoma cells.
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
IC50
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RADIOLIGAND->TARGET |
A serine/threonine kinase PET
imaging agent for the melanomas mainly in the specific expression of the BRAFV600E mutation.
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
An ATP competitive inhibitor. Binding assay
COMPETITIVE INHIBITOR
IC50
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INHIBITOR -> TARGET |
PRECLINICAL
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| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| MOL_WEIGHT:NUMBER(CALCULATED) | CHEMICAL |
|