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Approval Year

Substance Class Protein
Created
by admin
on Tue Apr 01 21:45:57 GMT 2025
Edited
by admin
on Tue Apr 01 21:45:57 GMT 2025
Protein Type ENZYME
Protein Sub Type SERINE/THREONINE-PROTEIN KINASE
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
U7FKT8J0J3
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BRAF V600E
Preferred Name English
SERINE/THREONINE-PROTEIN KINASE B-RAF V600E
Common Name English
Code System Code Type Description
UNIPROT
P15056
Created by admin on Tue Apr 01 21:45:57 GMT 2025 , Edited by admin on Tue Apr 01 21:45:57 GMT 2025
PRIMARY
FDA UNII
U7FKT8J0J3
Created by admin on Tue Apr 01 21:45:57 GMT 2025 , Edited by admin on Tue Apr 01 21:45:57 GMT 2025
PRIMARY
Related Record Type Details
INHIBITOR -> TARGET
In contrast to approved therapies targeting Class I V600E BRAF mutant tumors, KIN-2787 was active across all classes of BRAF-altered melanoma cells.
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
IC50
RADIOLIGAND->TARGET
A serine/threonine kinase PET imaging agent for the melanomas mainly in the specific expression of the BRAFV600E mutation.
INHIBITOR -> TARGET
INHIBITOR -> TARGET
An ATP competitive inhibitor. Binding assay
COMPETITIVE INHIBITOR
IC50
WEAK INHIBITOR->TARGET
IC50
INHIBITOR -> TARGET
PRECLINICAL
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL