FLORTANIDAZOLE F-18

Investigational

Details

Stereochemistry	RACEMIC
Molecular Formula	C9H11FN6O3
Molecular Weight	269.223
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OCC(C[18F])N1C=C(CN2C=CN=C2[N+]([O-])=O)N=N1

InChI

InChIKey=ZSSPATINHRVRTN-LMANFOLPSA-N

InChI=1S/C9H11FN6O3/c10-3-8(6-17)15-5-7(12-13-15)4-14-2-1-11-9(14)16(18)19/h1-2,5,8,17H,3-4,6H2/i10-1

HIDE SMILES / InChI

Molecular Formula	C9H11FN6O3
Molecular Weight	269.223
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/mesh/67553729 | https://www.ncbi.nlm.nih.gov/pubmed/29980581

FLORTANIDAZOLE F-18 is a radioactive tumor hypoxia tracer to potentially identify and quantify the degree of hypoxia in tumors in vivo via positron emission tomography (PET) imaging.

Originator

Approval Year

PubMed

Title	Date	PubMed
18F-Flortanidazole Hypoxia PET Holds Promise as a Prognostic and Predictive Imaging Biomarker in a Lung Cancer Xenograft Model Treated with Metformin and Radiotherapy.	2019-01	29980581
Comparison of [18F]-FMISO, [18F]-FAZA and [18F]-HX4 for PET imaging of hypoxia--a simulation study.	2015	26203928
A comparison of the imaging characteristics and microregional distribution of 4 hypoxia PET tracers.	2014-03	24491409

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:22:01 GMT 2025` Edited by `admin` on `Mon Mar 31 18:22:01 GMT 2025`
Record UNII	U6954O3II9
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FLORTANIDAZOLE (18F)

Preferred Name

English

FLORTANIDAZOLE F-18

Common Name

English

(F-18)HX4

Code

English

Flortanidazole (18f) [WHO-DD]

Common Name

English

(±)-(F-18)HX4

Code

English

flortanidazole (¹?F) [INN]

Common Name

English

(18F)HX 4

Code

English

1H-1,2,3-TRIAZOLE-1-ETHANOL, .BETA.-(FLUORO-18F-METHYL)-4-((2-NITRO-1H-IMIDAZOL-1-YL)METHYL)-

Common Name

English

HX-4 F-18

Code

English

(F-18)HX4, (±)-

Code

English

Code System Code Type Description

NCI_THESAURUS

C169986