FLORTANIDAZOLE F-18

Details

Stereochemistry	RACEMIC
Molecular Formula	C9H11FN6O3
Molecular Weight	269.223
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OCC(C[18F])N1C=C(CN2C=CN=C2[N+]([O-])=O)N=N1

InChI

InChIKey=ZSSPATINHRVRTN-LMANFOLPSA-N

InChI=1S/C9H11FN6O3/c10-3-8(6-17)15-5-7(12-13-15)4-14-2-1-11-9(14)16(18)19/h1-2,5,8,17H,3-4,6H2/i10-1

HIDE SMILES / InChI

Molecular Formula	C9H11FN6O3
Molecular Weight	269.223
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/mesh/67553729 | https://www.ncbi.nlm.nih.gov/pubmed/29980581

FLORTANIDAZOLE F-18 is a radioactive tumor hypoxia tracer to potentially identify and quantify the degree of hypoxia in tumors in vivo via positron emission tomography (PET) imaging.

Originator

Approval Year

PubMed

Title	Date	PubMed
A comparison of the imaging characteristics and microregional distribution of 4 hypoxia PET tracers.	2014 Mar	24491409
Comparison of [18F]-FMISO, [18F]-FAZA and [18F]-HX4 for PET imaging of hypoxia--a simulation study.	2015	26203928
(18)F-Flortanidazole Hypoxia PET Holds Promise as a Prognostic and Predictive Imaging Biomarker in a Lung Cancer Xenograft Model Treated with Metformin and Radiotherapy.	2019 Jan	29980581

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:12:46 UTC 2023` Edited by `admin` on `Fri Dec 15 16:12:46 UTC 2023`
Record UNII	U6954O3II9
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

FLORTANIDAZOLE F-18

Common Name

English

(F-18)HX4

Code

English

Flortanidazole (18f) [WHO-DD]

Common Name

English

FLORTANIDAZOLE (18F)

Official Name

English

(±)-(F-18)HX4

Code

English

flortanidazole (¹⁸F) [INN]

Common Name

English

(18F)HX 4

Code

English

1H-1,2,3-TRIAZOLE-1-ETHANOL, .BETA.-(FLUORO-18F-METHYL)-4-((2-NITRO-1H-IMIDAZOL-1-YL)METHYL)-

Common Name

English

HX-4 F-18

Code

English

(F-18)HX4, (±)-

Code

English

Code System Code Type Description

NCI_THESAURUS

C169986

Created by admin on Fri Dec 15 16:12:47 UTC 2023 , Edited by admin on Fri Dec 15 16:12:47 UTC 2023

PRIMARY

INN

9721

Created by admin on Fri Dec 15 16:12:46 UTC 2023 , Edited by admin on Fri Dec 15 16:12:46 UTC 2023

PRIMARY

SMS_ID

100000178038

Created by admin on Fri Dec 15 16:12:47 UTC 2023 , Edited by admin on Fri Dec 15 16:12:47 UTC 2023

PRIMARY

CAS

1070878-86-2

Created by admin on Fri Dec 15 16:12:46 UTC 2023 , Edited by admin on Fri Dec 15 16:12:46 UTC 2023

PRIMARY

NCI_THESAURUS

C171886

Created by admin on Fri Dec 15 16:12:47 UTC 2023 , Edited by admin on Fri Dec 15 16:12:47 UTC 2023

ALTERNATIVE

PUBCHEM

25183380

Created by admin on Fri Dec 15 16:12:47 UTC 2023 , Edited by admin on Fri Dec 15 16:12:47 UTC 2023

PRIMARY

FDA UNII

U6954O3II9

Created by admin on Fri Dec 15 16:12:46 UTC 2023 , Edited by admin on Fri Dec 15 16:12:46 UTC 2023

PRIMARY

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ACTIVE MOIETY

Amount:

Details

SMILES

InChI

DescriptionSources: https://www.ncbi.nlm.nih.gov/mesh/67553729 | https://www.ncbi.nlm.nih.gov/pubmed/29980581

Originator

Approval Year

PubMed

Patents

Description
Sources: https://www.ncbi.nlm.nih.gov/mesh/67553729 | https://www.ncbi.nlm.nih.gov/pubmed/29980581