Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C18H19F3N6O2 |
| Molecular Weight | 408.3777 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NC(=N)NC(=O)C1=CC=C(N2CCN(CC2)C(=O)C3=CC=CN3)C(=C1)C(F)(F)F
InChI
InChIKey=SRRHGTUDJFMQIV-UHFFFAOYSA-N
InChI=1S/C18H19F3N6O2/c19-18(20,21)12-10-11(15(28)25-17(22)23)3-4-14(12)26-6-8-27(9-7-26)16(29)13-2-1-5-24-13/h1-5,10,24H,6-9H2,(H4,22,23,25,28)
| Molecular Formula | C18H19F3N6O2 |
| Molecular Weight | 408.3777 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Sabiporide was developed as a specific Na(+)/H(+) exchanger (NHE1) inhibitor. Sabiporide possessed a cardioprotective effect that was shown in a preclinical model of myocardial infarction in the rat. In addition, experiments on rodents have revealed that the administration of sabiporide improved cardiovascular function and attenuates organ injury from severe sepsis. However, the development of this drug appears to be discontinued.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Protection of rat heart myocardium with a selective Na(+)/H(+) exchange inhibitor and ischemic preconditioning]. | 2005 |
|
| An integral approach to the etiopathogenesis of human neurodegenerative diseases (HNDDs) and cancer. Possible therapeutic consequences within the frame of the trophic factor withdrawal syndrome (TFWS). | 2008 Dec |
|
| The effect of Na(+)/H(+) exchanger-1 inhibition by sabiporide on blood-brain barrier dysfunction after ischemia/hypoxia in vivo and in vitro. | 2010 Dec 17 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:28:40 GMT 2023
by
admin
on
Fri Dec 15 16:28:40 GMT 2023
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| Record UNII |
U52APA00X7
|
| Record Status |
Validated (UNII)
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| Record Version |
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Download
| Name | Type | Language | ||
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Official Name | English | ||
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Common Name | English |
| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C47793
Created by
admin on Fri Dec 15 16:28:40 GMT 2023 , Edited by admin on Fri Dec 15 16:28:40 GMT 2023
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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CHEMBL2105423
Created by
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U52APA00X7
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admin on Fri Dec 15 16:28:40 GMT 2023 , Edited by admin on Fri Dec 15 16:28:40 GMT 2023
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9868115
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300000036940
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324758-66-9
Created by
admin on Fri Dec 15 16:28:40 GMT 2023 , Edited by admin on Fri Dec 15 16:28:40 GMT 2023
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8071
Created by
admin on Fri Dec 15 16:28:40 GMT 2023 , Edited by admin on Fri Dec 15 16:28:40 GMT 2023
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C476560
Created by
admin on Fri Dec 15 16:28:40 GMT 2023 , Edited by admin on Fri Dec 15 16:28:40 GMT 2023
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C74228
Created by
admin on Fri Dec 15 16:28:40 GMT 2023 , Edited by admin on Fri Dec 15 16:28:40 GMT 2023
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PRIMARY |
| Related Record | Type | Details | ||
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TARGET -> INHIBITOR |
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| Related Record | Type | Details | ||
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ACTIVE MOIETY |
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