U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C11H18O3
Molecular Weight 198.2588
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of JTT-608

SMILES

C[C@H]1CC[C@@H](CC1)C(=O)CCC(O)=O

InChI

InChIKey=JOWMTYWOBJALGB-KYZUINATSA-N
InChI=1S/C11H18O3/c1-8-2-4-9(5-3-8)10(12)6-7-11(13)14/h8-9H,2-7H2,1H3,(H,13,14)/t8-,9-

HIDE SMILES / InChI

Molecular Formula C11H18O3
Molecular Weight 198.2588
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
PubMed

PubMed

TitleDatePubMed
Daily inhibition of postprandial hyperglycaemia with JTT-608, a novel oral antidiabetic agent, ameliorates pancreatic function in neonatally streptozotocin-treated rats.
2005-09
Antidiabetic effect of chronic administration of JTT-608, a new hypoglycemic agent, in diabetic Goto-Kakizaki rats.
2003-08-22
A novel enhancer of insulinotrophic action by high glucose (JTT-608) stimulates insulin secretion from pancreatic beta-cells via a new cellular mechanism.
2001-06
A new hypoglycemic agent, JTT-608, evokes protein kinase A-mediated Ca(2+) signaling in rat islet beta-cells: strict regulation by glucose, link to insulin release, and cooperation with glucagon-like peptide-1(7-36)amide and pituitary adenylate cyclase-activating polypeptide.
2001-01
Patents
Substance Class Chemical
Created
by admin
on Mon Mar 31 22:16:06 GMT 2025
Edited
by admin
on Mon Mar 31 22:16:06 GMT 2025
Record UNII
U419K07BFP
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CYCLOHEXANEBUTANOIC ACID, 4-METHYL-.GAMMA.-OXO-, TRANS-
Preferred Name English
JTT-608
Common Name English
Code System Code Type Description
FDA UNII
U419K07BFP
Created by admin on Mon Mar 31 22:16:06 GMT 2025 , Edited by admin on Mon Mar 31 22:16:06 GMT 2025
PRIMARY
CAS
195137-72-5
Created by admin on Mon Mar 31 22:16:06 GMT 2025 , Edited by admin on Mon Mar 31 22:16:06 GMT 2025
PRIMARY
PUBCHEM
6919096
Created by admin on Mon Mar 31 22:16:06 GMT 2025 , Edited by admin on Mon Mar 31 22:16:06 GMT 2025
PRIMARY
Related Record Type Details
ACTIVE MOIETY