PNU-142721

C[C@H](SC1=NC(Cl)=CC(N)=N1)C2=NC=C3OC=CC3=C2

InChIKey=ATCRIOJPQXDFNY-ZETCQYMHSA-N

InChI=1S/C13H11ClN4OS/c1-7(20-13-17-11(14)5-12(15)18-13)9-4-8-2-3-19-10(8)6-16-9/h2-7H,1H3,(H2,15,17,18)/t7-/m0/s1

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

PubMed

Title	Date	PubMed
Structural basis for the inhibitory efficacy of efavirenz (DMP-266), MSC194 and PNU142721 towards the HIV-1 RT K103N mutant.	2002-03	11895437
(-)-6-Chloro-2-[(1-furo[2, 3-c]pyridin-5-ylethyl)thio]-4-pyrimidinamine, PNU-142721, a new broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitor.	1998-04-23	9554867

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:29:28 GMT 2025` Edited by `admin` on `Mon Mar 31 18:29:28 GMT 2025`
Record UNII	U3D0LYB7P0
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

(-)-PNU-142721

Preferred Name

English

PNU-142721

Common Name

English

4-PYRIMIDINAMINE, 6-CHLORO-2-(((1S)-1-FURO(2,3-C)PYRIDIN-5-YLETHYL)THIO)-

Systematic Name

English

4-PYRIMIDINAMINE, 6-CHLORO-2-((1-FURO(2,3-C)PYRIDIN-5-YLETHYL)THIO)-, (S)-

Systematic Name

English

Code System Code Type Description

PUBCHEM

446309