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Details

Stereochemistry ACHIRAL
Molecular Formula C19H15Cl3O5
Molecular Weight 429.678
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of NORNIDULIN

SMILES

C\C=C(\C)C1=C2OC3=C(C(C)=C(Cl)C(O)=C3Cl)C(=O)OC2=C(C)C(O)=C1Cl

InChI

InChIKey=XEQDVQKKHOQZEP-WAYWQWQTSA-N
InChI=1S/C19H15Cl3O5/c1-5-6(2)9-12(21)14(23)8(4)16-18(9)26-17-10(19(25)27-16)7(3)11(20)15(24)13(17)22/h5,23-24H,1-4H3/b6-5-

HIDE SMILES / InChI

Molecular Formula C19H15Cl3O5
Molecular Weight 429.678
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Description

Nornidulin is a depsidone produced by several fungal species with potent and selective antibacterial activity. Nornidulin inhibited aromatase with IC50 value of 4.6 uM. Nornidulin suppresses nitric oxide production in RAW 264.7 cells.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
4.6 µM [IC50]
25.69 µM [IC50]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

PubMed

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Nornidulin inhibited aromatase with IC50 value of 4.6 uM. It weakly inhibited MOLT-3 cells with IC50 value of 35.7 uM.
Substance Class Chemical
Record UNII
U3A9D130C9
Record Status Validated (UNII)
Record Version