AXICABTAGENE CILOLEUCEL

Approval Year

Substance Class	Structurally Diverse
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	BLOOD
Fraction Material Type	CELL
Fraction Name	CD4 AND CD8 POSITIVE
Record UNII	U2I8T43Y7R
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AXICABTAGENE CILOLEUCEL

Official Name

English

Axicabtagene ciloleucel [WHO-DD]

Common Name

English

axicabtagene ciloleucel [INN]

Common Name

English

YESCARTA

Brand Name

English

AUTOLOGOUS T CELLS TRANSDUCED WITH RETROVIRAL VECTOR ENCODING AN ANTI-CD-19 CD28/CD3-ZETA CHIMERIC ANTIGEN RECEPTOR

Common Name

English

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Classification Tree

Code System

Code

Adoptive Cell Therapy Agent

NCI_THESAURUS

C129826

Designated/Approved

FDA ORPHAN DRUG

515615

Designated

FDA ORPHAN DRUG

735920

Adoptive Cell Therapy Agent

NCI_THESAURUS

C28681

Designated/Approved

FDA ORPHAN DRUG

423914

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Code System

Code

Type

Description

USAN

DE-33

PRIMARY

DRUG BANK

DB13915

PRIMARY

RXCUI

1987398

PRIMARY

DAILYMED

U2I8T43Y7R

PRIMARY

NCI_THESAURUS

C120309

PRIMARY

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Related Record

Type

Details


					U2I8T43Y7R

AXICABTAGENE CILOLEUCEL

ACTIVE MOIETY

Amount:

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Agent Modifications

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Modification Process	Modification Role	Modification Type	Fragment Name	Fragment ID
CULTURE	ACTIVATOR	IMMUNOLOGICAL	MUROMONAB-CD3	JGA39ICE2V
CULTURE	GROWTH FACTOR	BIOLOGICAL	ALDESLEUKIN	M89N0Q7EQR
TRANSDUCTION	ANTIGEN EXPRESSION	TRANSDUCING VECTOR	UNSPECIFIED SUBSTANCE	0f2235db

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Structural Modifications

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Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
MOIETY					ANTI-CD-19 CD28/CD3-ZETA CHIMERIC ANTIGEN RECEPTOR (KTE-CD19)	V248BS56D0

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