FLURPIRIDAZ F-18

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H22ClFN2O3
Molecular Weight	367.833
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)(C)N1N=CC(OCC2=CC=C(COCC[18F])C=C2)=C(Cl)C1=O

InChI

InChIKey=RMXZKEPDYBTFOS-LRFGSCOBSA-N

InChI=1S/C18H22ClFN2O3/c1-18(2,3)22-17(23)16(19)15(10-21-22)25-12-14-6-4-13(5-7-14)11-24-9-8-20/h4-7,10H,8-9,11-12H2,1-3H3/i20-1

HIDE SMILES / InChI

Molecular Formula	C18H22ClFN2O3
Molecular Weight	367.833
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.medicaldevice-network.com/news/ge-healthcare-initiates-new-phase-iii-trial-flurpiridaz-detect-cad/ | http://www.lantheus.com/pipeline/flurpiridaz-f-18/

Flurpiridaz F-18, a fluorine 18-labeled agent was developed by Lantheus Medical Imaging for the diagnosis of coronary artery disease (CAD), the most common form of heart disease, which affects an estimated 15.5 million Americans 20 years of age or older. Flurpiridaz F 18 is an investigational positron emission tomography (PET) myocardial perfusion imaging (MPI) agent. GE Healthcare has launched a second Phase III clinical trial for the use of Flurpiridaz 18F Injection in PET myocardial perfusion imaging (MPI) to detect CAD.

Originator

Approval Year

PubMed

Title	Date	PubMed
Will (18)F flurpiridaz replace (82)rubidium as the most commonly used perfusion tracer for PET myocardial perfusion imaging?	2019 Dec	30488324
Stability of Distribution of F18 Flurpiridaz After Transient Coronary Occlusion in Pigs.	2019 Nov	31326498

Patents

Sample Use Guides

In Vivo Use Guide

Injection of Flurpiridaz F18 for the purposes of PET myocardial profusion imaging (MPI) analysis

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:54:36 UTC 2023` Edited by `admin` on `Fri Dec 15 18:54:36 UTC 2023`
Record UNII	TY3V24C029
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FLURPIRIDAZ F-18

Common Name

English

4-CHLORO-2-(1,1-DIMETHYLETHYL)-5-((4-((2-((SUP 18)F)FLUOROETHOXY)METHYL)PHENYL) METHOXY)PYRIDAZIN-3(2H)-ONE

Common Name

English

3(2H)-PYRIDAZINONE, 4-CHLORO-2-(1,1-DIMETHYLETHYL)-5-((4-((2-(FLUORO-18F)ETHOXY)METHYL)PHENYL)METHOXY)-

Common Name

English

BMS-747158-02

Code

English

2-TERT-BUTYL-4-CHLORO-5-((4-((2-(18F)FLUOROETHOXY)METHYL)PHENYL)METHOXY)PYRIDAZIN-3(2H)-ONE

Common Name

English

FLURPIRIDAZ F 18

Official Name

English

FLURPIRIDAZ, F-18

Common Name

English

FLURPIRIDAZ F 18 [USAN]

Common Name

English

flurpiridaz (¹⁸F) [INN]

Common Name

English

FLURPIRIDAZ (18F)

Official Name

English

3(2H)-PYRIDAZINONE, 4-CHLORO-2-(1,1-DIMETHYLETHYL)-5-((4-((2-(FLUORO-(SUP 18)F)ETHOXY)METHYL)PHENYL)METHOXY)-

Common Name

English

Flurpiridaz (18f) [WHO-DD]

Common Name

English

BMS-747158

Code

English

BMS 747158-02

Code

English

Code System Code Type Description

PUBCHEM

11405965