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Details

Stereochemistry ACHIRAL
Molecular Formula C11H15N3O2S
Molecular Weight 253.321
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of VERDIPERSTAT

SMILES

CC(C)OCCN1C2=C(NC=C2)C(=O)NC1=S

InChI

InChIKey=FVJCUZCRPIMVLB-UHFFFAOYSA-N
InChI=1S/C11H15N3O2S/c1-7(2)16-6-5-14-8-3-4-12-9(8)10(15)13-11(14)17/h3-4,7,12H,5-6H2,1-2H3,(H,13,15,17)

HIDE SMILES / InChI
Molecular Formula C11H15N3O2S
Molecular Weight 253.321
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Verdiperstat (formerly known as AZD 3241) was developed as a selective inhibitor of myeloperoxidase, an enzyme that acts as a key driver of pathological oxidative stress and inflammation in the brain. Verdiperstat was studied in patients with a number of neurodegenerative disorders, including multiple system atrophy and Parkinson's disease. Verdiperstat participated in phase II clinical trials for both diseases. As a result, studies for Parkinson disease were discontinued. In the case of multiple system atrophy, the drug has received the orphan drug status.

CNS Activity

Originator

Approval Year

Unknown
149124
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
0.31 nmol/mL
EXPERIMENT
https://accp1.onlinelibrary.wiley.com/doi/epdf/10.1002/jcph.1134
50 mg 1 times / day steady-state, oral
dose: 50 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
VERDIPERSTAT plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
0.74 nmol/mL
EXPERIMENT
https://accp1.onlinelibrary.wiley.com/doi/epdf/10.1002/jcph.1134
100 mg 1 times / day steady-state, oral
dose: 100 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
VERDIPERSTAT plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
1.18 nmol/mL
EXPERIMENT
https://accp1.onlinelibrary.wiley.com/doi/epdf/10.1002/jcph.1134
200 mg 1 times / day steady-state, oral
dose: 200 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
VERDIPERSTAT plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
1.9 nmol/mL
EXPERIMENT
https://accp1.onlinelibrary.wiley.com/doi/epdf/10.1002/jcph.1134
300 mg 1 times / day steady-state, oral
dose: 300 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
VERDIPERSTAT plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
5.2 nmol/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/29873817/
600 mg 1 times / day steady-state, oral
dose: 600 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
VERDIPERSTAT plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
6.9 nmol/mL
EXPERIMENT
https://accp1.onlinelibrary.wiley.com/doi/epdf/10.1002/jcph.1134
900 mg 1 times / day steady-state, oral
dose: 900 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
VERDIPERSTAT plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
2.38 nmol/mL
EXPERIMENT
https://accp1.onlinelibrary.wiley.com/doi/epdf/10.1002/jcph.1134
300 mg 1 times / day steady-state, oral
dose: 300 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
VERDIPERSTAT plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
4.15 nmol/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/29873817/
600 mg 1 times / day steady-state, oral
dose: 600 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
VERDIPERSTAT plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
2.64 nmol × h/mL
EXPERIMENT
https://accp1.onlinelibrary.wiley.com/doi/epdf/10.1002/jcph.1134
50 mg 1 times / day steady-state, oral
dose: 50 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
VERDIPERSTAT plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
6.46 nmol × h/mL
EXPERIMENT
https://accp1.onlinelibrary.wiley.com/doi/epdf/10.1002/jcph.1134
100 mg 1 times / day steady-state, oral
dose: 100 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
VERDIPERSTAT plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
10.6 nmol × h/mL
EXPERIMENT
https://accp1.onlinelibrary.wiley.com/doi/epdf/10.1002/jcph.1134
200 mg 1 times / day steady-state, oral
dose: 200 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
VERDIPERSTAT plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
17 nmol × h/mL
EXPERIMENT
https://accp1.onlinelibrary.wiley.com/doi/epdf/10.1002/jcph.1134
300 mg 1 times / day steady-state, oral
dose: 300 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
VERDIPERSTAT plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
49.4 nmol × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/29873817/
600 mg 1 times / day steady-state, oral
dose: 600 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
VERDIPERSTAT plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
62.5 nmol × h/mL
EXPERIMENT
https://accp1.onlinelibrary.wiley.com/doi/epdf/10.1002/jcph.1134
900 mg 1 times / day steady-state, oral
dose: 900 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
VERDIPERSTAT plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
21.2 nmol × h/mL
EXPERIMENT
https://accp1.onlinelibrary.wiley.com/doi/epdf/10.1002/jcph.1134
300 mg 1 times / day steady-state, oral
dose: 300 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
VERDIPERSTAT plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
39.5 nmol × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/29873817/
600 mg 1 times / day steady-state, oral
dose: 600 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
VERDIPERSTAT plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
2.5 h
REVIEW
https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Verdiperstat-Cognitive-Vitality-For-Researchers.pdf
600 mg 2 times / day multiple, oral
dose: 600 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
VERDIPERSTAT plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
PubMed

PubMed

TitleDatePubMed
Population Pharmacokinetic Modeling With Enterohepatic Circulation for AZD3241 in Healthy Subjects and Patients With Multiple System Atrophy.
2018-11
Failure of Neuroprotection Despite Microglial Suppression by Delayed-Start Myeloperoxidase Inhibition in a Model of Advanced Multiple System Atrophy: Clinical Implications.
2015-10
Development of rapid multistep carbon-11 radiosynthesis of the myeloperoxidase inhibitor AZD3241 to assess brain exposure by PET microdosing.
2015-06
Patents

Patents

07829707
1
20080221136
1
JP2008522968A
1

Sample Use Guides

In Vivo Use Guide
Drug: AZD3241 administered for 12 weeks orally as a tablet.
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Mon Mar 31 20:58:27 GMT 2025
Edited
by admin
on Mon Mar 31 20:58:27 GMT 2025
Record UNII
TT3345YXVR
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
verdiperstat [INN]
Preferred Name English
VERDIPERSTAT
INN   WHO-DD  
INN   USAN  
Official Name English
AZD 3241 [WHO-DD]
Common Name English
1-(2-ISOPROPOXYETHYL)-2-THIOXO-1,2,3,5-TETRAHYDROPYRROLO(3,2-D)PYRIMIDIN-4-ONE
Systematic Name English
1-(2-ISOPROPOXYETHYL)-2-THIOXO-1,2,3,5-TETRAHYDRO-PYRROLO(3,2-D) PYRIMIDIN-4-ONE
Systematic Name English
AZD-3241
Common Name English
VERDIPERSTAT [USAN]
Common Name English
AZD3241
Code English
Verdiperstat [WHO-DD]
Common Name English
BHV-3241
Code English
Classification Tree Code System Code
EU-Orphan Drug EU/3/14/1404
Created by admin on Mon Mar 31 20:58:27 GMT 2025 , Edited by admin on Mon Mar 31 20:58:27 GMT 2025
NCI_THESAURUS C1509
Created by admin on Mon Mar 31 20:58:27 GMT 2025 , Edited by admin on Mon Mar 31 20:58:27 GMT 2025
FDA ORPHAN DRUG 671418
Created by admin on Mon Mar 31 20:58:27 GMT 2025 , Edited by admin on Mon Mar 31 20:58:27 GMT 2025
NCI_THESAURUS C471
Created by admin on Mon Mar 31 20:58:27 GMT 2025 , Edited by admin on Mon Mar 31 20:58:27 GMT 2025
Code System Code Type Description
CAS
890655-80-8
Created by admin on Mon Mar 31 20:58:27 GMT 2025 , Edited by admin on Mon Mar 31 20:58:27 GMT 2025
PRIMARY
DRUG BANK
DB12440
Created by admin on Mon Mar 31 20:58:27 GMT 2025 , Edited by admin on Mon Mar 31 20:58:27 GMT 2025
PRIMARY
NCI_THESAURUS
C152861
Created by admin on Mon Mar 31 20:58:27 GMT 2025 , Edited by admin on Mon Mar 31 20:58:27 GMT 2025
PRIMARY
SMS_ID
100000175356
Created by admin on Mon Mar 31 20:58:27 GMT 2025 , Edited by admin on Mon Mar 31 20:58:27 GMT 2025
PRIMARY
INN
10251
Created by admin on Mon Mar 31 20:58:27 GMT 2025 , Edited by admin on Mon Mar 31 20:58:27 GMT 2025
PRIMARY
FDA UNII
TT3345YXVR
Created by admin on Mon Mar 31 20:58:27 GMT 2025 , Edited by admin on Mon Mar 31 20:58:27 GMT 2025
PRIMARY
USAN
GH-157
Created by admin on Mon Mar 31 20:58:27 GMT 2025 , Edited by admin on Mon Mar 31 20:58:27 GMT 2025
PRIMARY
PUBCHEM
11528958
Created by admin on Mon Mar 31 20:58:27 GMT 2025 , Edited by admin on Mon Mar 31 20:58:27 GMT 2025
PRIMARY
Related Record Type Details
Structure of VERDIPERSTAT
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