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Details

Stereochemistry ABSOLUTE
Molecular Formula C17H25NO3
Molecular Weight 291.3853
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 3
Charge 0

SHOW SMILES / InChI
Structure of PECILOCIN

SMILES

CCCC[C@@H](O)\C=C(C)\C=C\C=C\C(=O)N1CCCC1=O

InChI

InChIKey=ZYPGADGCNXOUJP-CXVPHVKISA-N
InChI=1S/C17H25NO3/c1-3-4-9-15(19)13-14(2)8-5-6-10-16(20)18-12-7-11-17(18)21/h5-6,8,10,13,15,19H,3-4,7,9,11-12H2,1-2H3/b8-5+,10-6+,14-13+/t15-/m1/s1

HIDE SMILES / InChI
Molecular Formula C17H25NO3
Molecular Weight 291.3853
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 3
Optical Activity UNSPECIFIED

Description

Variotin (Pecilocin), an antifungal antibiotic, is produced by Paecilomyces varioti Bainer var. antibioticus and was isolated by Takeuchi et al. (1959). It is used topically for the treatment of human dermatomycosis.

Originator

Takeuchi, S. et al.
1

Approval Year

Unknown
139,594

Conditions

ConditionModalityTargetsHighest PhaseProduct
Dermatomycosis
20
 Curative
Approved
8,429
Pecilocin

PubMed

Patents

US3122574
1
WO2009062746A2
2
WO2011075654A1
1

Sample Use Guides

In Vivo Use Guide
3,000 U/g ointment (guinea pig)
Route of Administration: Topical
In Vitro Use Guide
Variotin (Pecilocin) inhibits a number of fungi pathogenic to man such as Blastomyces dermatitidis, Trichophyton rubrum and Microsporum audouini at 0.25 μg/ml or less
Substance Class Chemical
Record UNII
TSA7W27MF8
Record Status Validated (UNII)
Record Version
NIH
NCATS
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