PECILOCIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C17H25NO3
Molecular Weight	291.3853
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	3
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCC[C@@H](O)\C=C(C)\C=C\C=C\C(=O)N1CCCC1=O

InChI

InChIKey=ZYPGADGCNXOUJP-CXVPHVKISA-N

InChI=1S/C17H25NO3/c1-3-4-9-15(19)13-14(2)8-5-6-10-16(20)18-12-7-11-17(18)21/h5-6,8,10,13,15,19H,3-4,7,9,11-12H2,1-2H3/b8-5+,10-6+,14-13+/t15-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C17H25NO3
Molecular Weight	291.3853
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	3
Optical Activity	UNSPECIFIED

Description
Sources: http://link.springer.com/chapter/10.1007%2F978-3-662-38441-1_17
Curator's Comment: Information on Pecilocin is too limited

Variotin (Pecilocin), an antifungal antibiotic, is produced by Paecilomyces varioti Bainer var. antibioticus and was isolated by Takeuchi et al. (1959). It is used topically for the treatment of human dermatomycosis.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Dermatomycosis 20 Sources: http://link.springer.com/chapter/10.1007%2F978-3-662-38441-1_17	Curative		Approved 8429	Pecilocin Approved Use Dermatomycosis

PubMed

Title	Date	PubMed
Studies on variotin, a new antifungal antibiotic. I. Preparations and properties of variotin.	1959 Sep	13855011
Studies on variotin, a new antifungal antibiotic. II. Taxonomical studies on variotin-producing strain.	1959 Sep	13848726

Patents

Sample Use Guides

In Vivo Use Guide

3,000 U/g ointment (guinea pig)

Route of Administration: Topical

In Vitro Use Guide

Variotin (Pecilocin) inhibits a number of fungi pathogenic to man such as Blastomyces dermatitidis, Trichophyton rubrum and Microsporum audouini at 0.25 μg/ml or less

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:40:48 GMT 2023` Edited by `admin` on `Fri Dec 15 15:40:48 GMT 2023`
Record UNII	TSA7W27MF8
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PECILOCIN

Official Name

English

2-PYRROLIDINONE, 1-((2E,4E,6E,8R)-8-HYDROXY-6-METHYL-1-OXO-2,4,6-DODECATRIENYL)-

Systematic Name

English

VARIOTIN [JAN]

Common Name

English

pecilocin [INN]

Common Name

English

Pecilocin [WHO-DD]

Common Name

English

NSC-291839

Code

English

PECILOCIN [MI]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C514