| Stereochemistry | ACHIRAL |
| Molecular Formula | C21H19N3O2S |
| Molecular Weight | 377.459 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCS(=O)(=O)N(CC1=CN=CC=C1)C2=CC=CC(=C2)C3=CC=C(C=C3)C#N
InChI
InChIKey=HDVYXILCBYGKGU-UHFFFAOYSA-N
InChI=1S/C21H19N3O2S/c1-2-27(25,26)24(16-18-5-4-12-23-15-18)21-7-3-6-20(13-21)19-10-8-17(14-22)9-11-19/h3-13,15H,2,16H2,1H3
| Molecular Formula | C21H19N3O2S |
| Molecular Weight | 377.459 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
CNS Activity
Originator
Approval Year
PubMed
Patents
Sample Use Guides
In the mouse model of stress-induced hyperthermia, CBiPES was administered subcutaneously at 100 mg/kg.
Route of Administration:
Other
mGluR2 potentiation was tested in cell lines that expressed each of the eight human mGlu receptor, mGlu1a, mGlu2, mGlu3, mGlu4a, mGlu5a, mGlu6, mGlu7a, or mGlu8a, in an AV-12 (ATCC-CRL9595) cell background that also stably expresses the rat glutamate aspartate transporter (EAAT-1 or GLAST). With the group II and III receptors (mGlu2/3/4/6/7/8), the promiscuous G protein Gα15 was also stably expressed. This allowed receptor activation to stimulate phospholipase C, increasing inositol triphosphate formation, and subsequently a transient rise of intracellular calcium. Quantitation utilized to be determined using a calcium-sensitive dye and a Fluorometric Imaging Plate Reader (FLIPR). Treatment with CBiPES potentiated glutamate-induced increase in intracellular calcium concentration with IC50 of 92.8 nM
