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Details

Stereochemistry RACEMIC
Molecular Formula C23H32N2O
Molecular Weight 352.513
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AB-005

SMILES

CN1CCCCC1CN2C=C(C(=O)C3C(C)(C)C3(C)C)C4=C2C=CC=C4

InChI

InChIKey=MOBWRRIAIHYXLB-UHFFFAOYSA-N
InChI=1S/C23H32N2O/c1-22(2)21(23(22,3)4)20(26)18-15-25(19-12-7-6-11-17(18)19)14-16-10-8-9-13-24(16)5/h6-7,11-12,15-16,21H,8-10,13-14H2,1-5H3

HIDE SMILES / InChI

Molecular Formula C23H32N2O
Molecular Weight 352.513
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
628.0 nM [EC50]
5.5 nM [Ki]
Substance Class Chemical
Created
by admin
on Sat Dec 16 11:51:14 GMT 2023
Edited
by admin
on Sat Dec 16 11:51:14 GMT 2023
Record UNII
TPY5M47AYQ
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AB-005
Common Name English
(1-((1-METHYL-2-PIPERIDINYL)METHYL)-1H-INDOL-3-YL)(2,2,3,3-TETRAMETHYLCYCLOPROPYL)-METHANONE
Systematic Name English
METHANONE, (1-((1-METHYL-2-PIPERIDINYL)METHYL)-1H-INDOL-3-YL)(2,2,3,3-TETRAMETHYLCYCLOPROPYL)-
Systematic Name English
Classification Tree Code System Code
WIKIPEDIA Designer-drugs-AB-005
Created by admin on Sat Dec 16 11:51:14 GMT 2023 , Edited by admin on Sat Dec 16 11:51:14 GMT 2023
Code System Code Type Description
EPA CompTox
DTXSID001017492
Created by admin on Sat Dec 16 11:51:14 GMT 2023 , Edited by admin on Sat Dec 16 11:51:14 GMT 2023
PRIMARY
FDA UNII
TPY5M47AYQ
Created by admin on Sat Dec 16 11:51:14 GMT 2023 , Edited by admin on Sat Dec 16 11:51:14 GMT 2023
PRIMARY
MANUFACTURER PRODUCT INFORMATION
AB-005
Created by admin on Sat Dec 16 11:51:14 GMT 2023 , Edited by admin on Sat Dec 16 11:51:14 GMT 2023
PRIMARY AB-005 is a synthetic cannabinoid (CB) built on a 1-((1-methylpiperidin-2-yl)methyl)-indole base that is characteristic of a series of potent CBs, including AM1220 (Item No. 9001055), AM1241 (Item No. 10010118), and AM1248 (Item No. 11282).1 The addition of a tetramethylcyclopropyl group has, in some cases, increased selectivity of synthetic CBs for the peripheral CB2 receptor.2 The physiological and toxicological properties of this compound have not been established. This product is intended for forensic and research applications.
PUBCHEM
11537652
Created by admin on Sat Dec 16 11:51:14 GMT 2023 , Edited by admin on Sat Dec 16 11:51:14 GMT 2023
PRIMARY
CAS
895155-25-6
Created by admin on Sat Dec 16 11:51:14 GMT 2023 , Edited by admin on Sat Dec 16 11:51:14 GMT 2023
PRIMARY
WIKIPEDIA
AB-005
Created by admin on Sat Dec 16 11:51:14 GMT 2023 , Edited by admin on Sat Dec 16 11:51:14 GMT 2023
PRIMARY AB-005 or (1-((1-methyl-2-piperidinyl)methyl)-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)-methanone is a designer drug offered by online vendors as a cannabimimetic agent. The structure and pharmacological activity of AB-005 was published in 2010, prior to its commercial availability in 2012, where it was reported to have high affinity for both CB1 (Ki = 5.5 nM) and CB2 receptors (Ki = 0.48 nM). AB-005 features groups found in other previously reported synthetic cannabinoids: the tetramethylcyclopropane group of UR-144 and XLR-11 as well as the (1-methyl-2-piperidinyl)methyl substituent of AM-1248 and AM-1220. No information regarding the in vivo activity of AB-005 has been published, and only anecdotal reports are known of its psychoactivity in humans. Psychoactive products in New Zealand containing this drug have been given interim approval under recent psychoactive substances legislation.
Related Record Type Details
ACTIVE MOIETY