ACETILDENAFIL

Details

Stereochemistry	ACHIRAL
Molecular Formula	C25H34N6O3
Molecular Weight	466.5759
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCC1=NN(C)C2=C1NC(=NC2=O)C3=CC(=CC=C3OCC)C(=O)CN4CCN(CC)CC4

InChI

InChIKey=RRBRQNALHKQCAI-UHFFFAOYSA-N

InChI=1S/C25H34N6O3/c1-5-8-19-22-23(29(4)28-19)25(33)27-24(26-22)18-15-17(9-10-21(18)34-7-3)20(32)16-31-13-11-30(6-2)12-14-31/h9-10,15H,5-8,11-14,16H2,1-4H3,(H,26,27,33)

HIDE SMILES / InChI

Molecular Formula	C25H34N6O3
Molecular Weight	466.5759
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/17914141
Curator's Comment: The description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/16901855 | https://www.ncbi.nlm.nih.gov/pubmed/18178354

Acetildenafil is an analog of the phosphodiesterase inhibitor sildenafil, named for a substitution of an acetyl group for a sulfonyl group. This compound has been identified in herbal products marketed as aphrodisiacs. The physiological and toxicological properties of this analog have not been elucidated.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Phosphodiesterase 5A 30 Target ID: CHEMBL1827 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18178354	Inhibitor 8297		7.6 nM [IC50]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Erectile dysfunction 35 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16982533	Primary		Basic research	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Structural identification of a new acetildenafil analogue from pre-mixed bulk powder intended as a dietary supplement.	2006 Sep	16901855

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 10:00:06 UTC 2023` Edited by `admin` on `Sat Dec 16 10:00:06 UTC 2023`
Record UNII	TP0E2BW57H
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ACETILDENAFIL

Common Name

English

HONGDENAFIL

Common Name

English

ACETILDENAFIL [NFLIS-DRUG]

Common Name

English

7H-PYRAZOLO(4,3-D)PYRIMIDIN-7-ONE, 5-(2-ETHOXY-5-(2-(4-ETHYL-1-PIPERAZINYL)ACETYL)PHENYL)-1,6-DIHYDRO-1-METHYL-3-PROPYL-

Systematic Name

English

7H-PYRAZOLO(4,3-D)PYRIMIDIN-7-ONE, 5-(2-ETHOXY-5-((4-ETHYL-1-PIPERAZINYL)ACETYL)PHENYL)-1,4-DIHYDRO-1-METHYL-3-PROPYL-

Systematic Name

English

Classification Tree Code System Code

WIKIPEDIA

Designer-drugs-Acetildenafil