ASP-9831

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H23N3O3
Molecular Weight	353.4149
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCC1=CC=C2N1N=C(COC)C(CCC(O)=O)=C2C3=CN=CC(C)=C3

InChI

InChIKey=UECHVFIKTBUKTP-UHFFFAOYSA-N

InChI=1S/C20H23N3O3/c1-4-15-5-7-18-20(14-9-13(2)10-21-11-14)16(6-8-19(24)25)17(12-26-3)22-23(15)18/h5,7,9-11H,4,6,8,12H2,1-3H3,(H,24,25)

HIDE SMILES / InChI

Molecular Formula	C20H23N3O3
Molecular Weight	353.4149
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 11:46:03 GMT 2023` Edited by `admin` on `Sat Dec 16 11:46:03 GMT 2023`
Record UNII	TK9MSV53AD
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ASP-9831

Common Name

English

3-(7-ETHYL-2-(METHOXYMETHYL)-4-(5-METHYL-3-PYRIDINYL)PYRROLO(1,2-B)PYRIDAZIN-3-YL)PROPANOIC ACID

Systematic Name

English

PYRROLO(1,2-B)PYRIDAZINE-3-PROPANOIC ACID, 7-ETHYL-2-(METHOXYMETHYL)-4-(5-METHYL-3-PYRIDINYL)-

Systematic Name

English

Code System Code Type Description

SMS_ID

300000042515

Created by admin on Sat Dec 16 11:46:03 GMT 2023 , Edited by admin on Sat Dec 16 11:46:03 GMT 2023

PRIMARY

CAS

728013-50-1

Created by admin on Sat Dec 16 11:46:03 GMT 2023 , Edited by admin on Sat Dec 16 11:46:03 GMT 2023

PRIMARY

FDA UNII

TK9MSV53AD

Created by admin on Sat Dec 16 11:46:03 GMT 2023 , Edited by admin on Sat Dec 16 11:46:03 GMT 2023

PRIMARY

PUBCHEM

10360713

Created by admin on Sat Dec 16 11:46:03 GMT 2023 , Edited by admin on Sat Dec 16 11:46:03 GMT 2023

PRIMARY

Related Record Type Details


					TK9MSV53AD

ASP-9831

ACTIVE MOIETY

Comments:

ASP9831 is a phosphodiesterase-4 inhibitor developed to treat nonalcoholic steatohepatitis (NASH) it showed potent anti-inflammatory and antifibrotic effects in preclinical studies. We evaluated the efficacy and safety of ASP9831 in patients with NASH. Despite a relevant mechanism of action, ASP9831 did not significantly alter the biochemical markers of NASH, compared with placebo, in a clinical trial. This highlights the difficulties of developing therapeutics for NASH and the need for more extensive preclinical testing of mechanisms of potential drug candidates. Clinicaltrialsregister.eu: 2005-001687-31; EudraCT numbers: 2007-002114-19.


					TK9MSV53AD

ASP-9831

ACTIVE MOIETY

Comments:

Originator: Astellas Pharma; Mechanism of Action: Type 4 cyclic nucleotide phosphodiesterase inhibitor; Highest Development Phase: Discontinued for Non-alcoholic steatohepatitis