Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C2Cl4 |
| Molecular Weight | 165.833 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
ClC(Cl)=C(Cl)Cl
InChI
InChIKey=CYTYCFOTNPOANT-UHFFFAOYSA-N
InChI=1S/C2Cl4/c3-1(4)2(5)6
| Molecular Formula | C2Cl4 |
| Molecular Weight | 165.833 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Tetrachloroethylene is a nonflammable colorless liquid. Other names for tetrachloroethylene include perchloroethylene, PCE, PERC, tetrachloroethene, and perchlor. Tetrachloroethylene is used as a dry cleaning agent and metal degreasing solvent. It is also used as a starting material (building block) for making other chemicals and is used in some consumer products. It has also been used in water repellants, paint removers, printing inks, glues, sealants, polishes, and lubricants. Tetrachloroethylene has been in commercial use since the early 1900s. Tetrachlorethylene has been suspected of causing some types of cancer, based on both human and animal evidence. Laboratory studies have found that ingesting or inhaling tetrachlorethylene increased the risk of liver cancer in mice. In rats, inhaling tetrachloethylene was linked to kidney cancer and a rare type of leukemia. EPA has classified tetrachloroethylene as likely to be carcinogenic to humans by all routes of exposurebased on suggestive evidence in epidemiological studies and conclusive evidence in rats (mononuclear cellleukemia) and mice (increased incidence of liver tumors). The International Agency for Research on Cancer(IARC) has classified tetrachloroethylene as probably carcinogenic to humans (Group 2A).
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Constructing terbium co-ordination polymers of 4,4'-bipyridine-N,N'-dioxide by means of diffusion solvent mixtures. | 2002-05-03 |
|
| Dechlorination of PCBs, CAHs, herbicides and pesticides neat and in soils at 25 degrees C using Na/NH3. | 2002-05-03 |
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| Tetrachloroethene reductive dehalogenase of Dehalospirillum multivorans: substrate specificity of the native enzyme and its corrinoid cofactor. | 2002-05 |
|
| PBPK modeling of the percutaneous absorption of perchloroethylene from a soil matrix in rats and humans. | 2002-05 |
|
| High temperature oxidation of C2Cl4/CH4 mixtures. | 2002-04-26 |
|
| Back diffusion of chlorinated solvent contaminants from a natural aquitard to a remediated aquifer under well-controlled field conditions: predictions and measurements. | 2002-03-28 |
|
| Interfacial tension of chlorinated aliphatic DNAPL mixtures as a function of organic phase composition. | 2002-03-15 |
|
| Renal toxicity of perchloroethylene and S-(1,2,2-trichlorovinyl)glutathione in rats and mice: sex- and species-dependent differences. | 2002-03-15 |
|
| Exchange of organic solvents between the atmosphere and grass--the use of open top chambers. | 2002-02-21 |
|
| Specific UV absorbance of Aldrich humic acid: changes during transport in aquifer sediment. | 2002-02-15 |
|
| Kinetics and mechanism of oxidation of tetrachloroethylene with permanganate. | 2002-02 |
|
| Chronic toxicity of a mixture of chlorinated alkanes and alkenes in ICR mice. | 2002-02 |
|
| Health risk assessment on residents exposed to chlorinated hydrocarbons contaminated in groundwater of a hazardous waste site. | 2002-02 |
|
| Effects of retrofit emission controls and work practices on perchloroethylene exposures in small dry-cleaning shops. | 2002-02 |
|
| An evaluation of retrofit engineering control interventions to reduce perchloroethylene exposures in commercial dry-cleaning shops. | 2002-02 |
|
| Synthesis and characterization of chlorinated alkenylcobaloximes to probe the mechanism of vitamin B(12)-catalyzed dechlorination of priority pollutants. | 2002-01-28 |
|
| Behavioural effects of tetrachloroethylene exposure in rats: acute and subchronic studies. | 2002-01-25 |
|
| Implications of alcohol partitioning behavior for in situ density modification of entrapped dense nonaqueous phase liquids. | 2002-01-01 |
|
| Setting information priorities for remediation decisions at a contaminated-groundwater site. | 2002-01 |
|
| Simulated formation and flow of microemulsions during surfactant flushing of contaminated soil. | 2002-01 |
|
| The cytotoxicity of some organic solvents on isolated hepatocytes in monolayer culture. | 2002 |
|
| Tetrachloroethylene (TCE) removal during anaerobic granulation in an upflow anaerobic sludge blanket (UASB) reactor. | 2002 |
|
| Effects of various environmental conditions on the transformation of chlorinated solvents by Methanosarcina thermophila cell exudates. | 2001-12-20 |
|
| Hydrogen concentrations in sulfate-reducing estuarine sediments during PCE dehalogenation. | 2001-12-15 |
|
| Industrial chemicals and the horse. | 2001-12 |
|
| Sorptive interactions between VOCs and indoor materials. | 2001-12 |
|
| Gaseous transport of volatile organic chemicals in unsaturated porous media: effect of water-partitioning and air-water interfacial adsorption. | 2001-11-15 |
|
| Tetrachloroethylene in drinking water and birth outcomes at the US Marine Corps Base at Camp Lejeune, North Carolina. | 2001-11-15 |
|
| Investigation of mechanisms for the reductive dechlorination of chlorinated ethylenes using electroanalytical techniques. | 2001-11 |
|
| Co-metabolic degradation of chlorinated hydrocarbons by Pseudomonas sp. strain DCA1. | 2001-11 |
|
| A method of estimating multicomponent nonaqueous-phase liquid mass in porous media using aqueous concentration ratios. | 2001-11 |
|
| Protective role of vitamin E, 2-deoxy-D-glucose, and taurine on perchloroethylene induced alterations in ATPases. | 2001-11 |
|
| Neoantigen formation and clastogenic action of HCFC-123 and perchloroethylene in human MCL-5 cells. | 2001-10-15 |
|
| The role of CYP forms in the metabolism and metabolic activation of HCFCs and other halocarbons. | 2001-10-15 |
|
| The application of physiologically based pharmacokinetic modelling in the analysis of occupational exposure to perchloroethylene. | 2001-10-15 |
|
| Oxidation of chlorinated ethenes by potassium permanganate: a kinetics study. | 2001-10-12 |
|
| Factors influencing rates and products in the transformation of trichloroethylene by iron sulfide and iron metal. | 2001-10-01 |
|
| Reductive dechlorination of tetrachloroethylene in soils by Fe(II)-based degradative solidification/stabilization. | 2001-09-15 |
|
| Synergistic effect of cationic surfactants on perchloroethylene degradation by zero-valent iron. | 2001-09-15 |
|
| Worker exposure to aromatic volatile organic compounds in dry cleaning stores. | 2001-09-11 |
|
| Remediation of NAPL-contaminated aquifers: is the cure worth the cost? | 2001-09 |
|
| Evaluating degradation rates of chlorinated organics in groundwater using analytical models. | 2001-09 |
|
| An in vitro model for evaluation of vaporous toxicity of trichloroethylene and tetrachloroethylene to CHO-K1 cells. | 2001-08-31 |
|
| Experimental upgrades of membrane introduction mass spectrometry for water and air analysis. | 2001-08-15 |
|
| Concentration variability of halocarbons over an electronics industrial park and its implication in compliance with the Montreal protocol. | 2001-08-15 |
|
| Tetrachloroethylene, trichloroethylene, and chlorinated phenols induce toluene-o-xylene monooxygenase activity in Pseudomonas stutzeri OX1. | 2001-08 |
|
| Isolation and characterization of Desulfitobacterium sp. strain Y51 capable of efficient dehalogenation of tetrachloroethene and polychloroethanes. | 2001-07 |
|
| Characteristic hydrogen concentrations for various redox processes in batch study. | 2001 |
|
| An improved method of hydrogen production as electron donor for anaerobic bioremediation. | 2001 |
|
| Occupational exposure to harmful chemical substances while processing phenol-formaldehyde resins. | 2001 |
Patents
Sample Use Guides
Tetrachloroethylene (30, 100, 300, and 1000 mg/kg) was administered by gavage in aqueous vehicle to male B6C3F1/J mice.
Route of Administration:
Oral
7-Pentoxyresorufin O-depentylase (PROD) and 7-benzyloxyresorufin O-debenzylase (BROD) activities in phenobarbital (PB)-treated rat liver microsomes were substantially inhibited by Tetrachloroethylene (PCE). The inhibition profiles were non-competitive for both enzyme activities; Ki's from Eadie-Hofsee plots were 0.16 and 0.29 mM for PROD and BROD respectively.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 17:46:56 GMT 2025
by
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on
Mon Mar 31 17:46:56 GMT 2025
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| Record UNII |
TJ904HH8SN
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| Record Status |
Validated (UNII)
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EPA PESTICIDE CODE |
78501
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NCI_THESAURUS |
C45386
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ACTIVE MOIETY |
