Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C18H25F3N4O |
| Molecular Weight | 370.4125 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
FC(F)(F)C1=CC(=NC=C1)N2CCN(CCCCN3CCCC3=O)CC2
InChI
InChIKey=YKJJCYZZWWSBEW-UHFFFAOYSA-N
InChI=1S/C18H25F3N4O/c19-18(20,21)15-5-6-22-16(14-15)24-12-10-23(11-13-24)7-1-2-8-25-9-3-4-17(25)26/h5-6,14H,1-4,7-13H2
| Molecular Formula | C18H25F3N4O |
| Molecular Weight | 370.4125 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Strychnine seizure potentiation by azaspirodecanedione anxiolytics in rats. | 1988 Oct 18 |
|
| Effects of 5-HT1A agonists and 5-HT2 antagonists on haloperidol-induced dyskinesias in squirrel monkeys: no evidence for reciprocal 5-HT-dopamine interaction. | 1989 |
|
| Prenatal exposure to cocaine: effects on aggression in Sprague-Dawley rats. | 1994 May |
|
| 5-HT1A receptor agonists buspirone and gepirone attenuate apomorphine-induced aggressive behaviour in adult male Wistar rats. | 2000 Dec |
|
| Involvement of 5-hydroxytryptamine(1A) receptors in nicotine-induced tail tremor in rats. | 2000 Nov 10 |
|
| Gepirone. Organon. | 2001 Aug |
|
| Effects of serotonergic compounds on aqueous humor dynamics in monkeys. | 2001 Aug |
|
| The clinical pharmacology of depressive states. | 2002 Mar |
|
| Rigid analogues of buspirone and gepirone, 5-HT1A receptors partial agonists. | 2002 Nov |
|
| 5-HT1A receptor-mediated regulation of mitogen-activated protein kinase phosphorylation in rat brain. | 2002 Oct 4 |
|
| Influence of housing conditions on the effects of serotonergic drugs on feeding behavior in non-deprived rats. | 2003 |
|
| Is there a role for 5-HT1A agonists in the treatment of depression? | 2003 Feb 1 |
|
| A review of the efficacy and tolerability of immediate-release and extended-release formulations of gepirone. | 2003 Jun |
|
| Gepirone extended-release: new evidence for efficacy in the treatment of major depressive disorder. | 2003 Mar |
|
| Human cytochromes mediating gepirone biotransformation at low substrate concentrations. | 2003 Mar |
|
| Differential effects of the 5-HT1A agonist gepirone on food intake in rats may depend on their motivation to eat. | 2003 Nov |
|
| Pharmacokinetic evaluation of gepirone immediate-release capsules and gepirone extended-release tablets in healthy volunteers. | 2003 Sep |
|
| The design and preparation of metabolically protected new arylpiperazine 5-HT1A ligands. | 2004 Apr 5 |
|
| Gepirone extended-release treatment of anxious depression: evidence from a retrospective subgroup analysis in patients with major depressive disorder. | 2004 Aug |
|
| [Review of antidepressants from the TCAs to the third generation drugs]. | 2004 Dec |
|
| Metabolism of the newest antidepressants: comparisons with related predecessors. | 2004 Feb |
|
| Cellular consequences of stress and depression. | 2004 Jun |
|
| Use of physicochemical calculation of pKa and CLogP to predict phospholipidosis-inducing potential: a case study with structurally related piperazines. | 2004 Mar |
|
| Sustained efficacy of gepirone-IR in major depressive disorder: a double-blind placebo substitution trial. | 2004 May-Jun |
|
| Relapse prevention with gepirone ER in outpatients with major depression. | 2005 Feb |
|
| Novel, flexible, and conformationally defined analogs of gepirone: synthesis and 5-HT1A, 5-HT2A, and D2 receptor activity. | 2005 Feb 15 |
|
| Remission rates with 3 consecutive antidepressant trials: effectiveness for depressed outpatients. | 2005 Jun |
|
| The 5-HT1A receptor and the stimulus effects of LSD in the rat. | 2005 Oct |
|
| Early response and 8-week treatment outcome in GAD. | 2006 |
|
| Acute and constitutive increases in central serotonin levels reduce social play behaviour in peri-adolescent rats. | 2007 Dec |
|
| Gepirone extended-release in the treatment of adult outpatients with major depressive disorder: a double-blind, randomized, placebo-controlled, parallel-group study. | 2008 Apr |
|
| Differential response to gepirone but not to chlordiazepoxide in malnourished rats subjected to learned helplessness. | 2008 Jan |
|
| Assessing the neuronal serotonergic target-based antidepressant stratagem: impact of in vivo interaction studies and knockout models. | 2008 Sep |
|
| Olanzapine and fluoxetine combination therapy for treatment-resistant depression: review of efficacy, safety, and study design issues. | 2009 |
|
| Emotional reactivity and cognitive performance in aversively motivated tasks: a comparison between four rat strains. | 2009 Dec 15 |
|
| Practical application of cure mixture model for long-term censored survivor data from a withdrawal clinical trial of patients with major depressive disorder. | 2010 Apr 23 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 10:17:34 GMT 2023
by
admin
on
Sat Dec 16 10:17:34 GMT 2023
|
| Record UNII |
TG6TYE3R9N
|
| Record Status |
Validated (UNII)
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| Record Version |
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DTXSID001037020
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142494-12-0
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9907401
Created by
admin on Sat Dec 16 10:17:34 GMT 2023 , Edited by admin on Sat Dec 16 10:17:34 GMT 2023
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TG6TYE3R9N
Created by
admin on Sat Dec 16 10:17:34 GMT 2023 , Edited by admin on Sat Dec 16 10:17:34 GMT 2023
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