HENATINIB

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C25H29FN4O4
Molecular Weight	468.5206
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=C(NC2=C1C(=O)N(C[C@H](O)CN3CCOCC3)CCC2)\C=C4/C(=O)NC5=C4C=C(F)C=C5

InChI

InChIKey=MCTXSDCWFQAGFS-UEXNTNOUSA-N

InChI=1S/C25H29FN4O4/c1-15-22(12-19-18-11-16(26)4-5-20(18)28-24(19)32)27-21-3-2-6-30(25(33)23(15)21)14-17(31)13-29-7-9-34-10-8-29/h4-5,11-12,17,27,31H,2-3,6-10,13-14H2,1H3,(H,28,32)/b19-12-/t17-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C25H29FN4O4
Molecular Weight	468.5206
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	1
Optical Activity	UNSPECIFIED

Description
Sources: https://clinicaltrials.gov/ct2/show/NCT01416623 | https://www.ncbi.nlm.nih.gov/pubmed/23587531 | https://adisinsight.springer.com/drugs/800037384

Henatinib was developed as a multitargeted tyrosine kinase inhibitor with antitumor activities. Henatinib is an endothelial growth factor receptor type 2 (VEGFR2) antagonist. The drug participated in phase I clinical trial to evaluate the safety and tolerability in patients with advanced solid malignancies, however, the study was terminated. The current development status is unknown.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Vascular endothelial growth factor receptor 2 104 Target ID: P35968 Gene ID: 3791.0 Gene Symbol: KDR Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/19662624	Antagonist 2778

PubMed

Title	Date	PubMed
Quantification of henatinib maleate, a novel potent inhibitor of VEGF receptors, in rat plasma by LC-MS/MS.	2010 Apr	19662624
Determination of henatinib in human plasma and urine by liquid chromatography-tandem mass spectrometry and its pharmacokinetic application.	2013 Jun	23587531

Patents

Sample Use Guides

In Vivo Use Guide

Henatinib either at 12.5,25,37.5,50,62.5,75,87.5 or 100 mg, p.o. once daily

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 07:09:26 UTC 2023` Edited by `admin` on `Sat Dec 16 07:09:26 UTC 2023`
Record UNII	TE20GB753F
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

HENATINIB

Common Name

English

PYRROLO(3,2-C)AZEPIN-4(1H)-ONE, 2-((Z)-(5-FLUORO-1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE)METHYL)-5,6,7,8-TETRAHYDRO-5-((2R)-2-HYDROXY-3-(4-MORPHOLINYL)PROPYL)-3-METHYL-

Systematic Name

English

Code System Code Type Description

ChEMBL

CHEMBL3545416