Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C24H29FNO3 |
| Molecular Weight | 398.4904 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Charge | 1 |
SHOW SMILES / InChI
SMILES
C[N@@+]1(CCF)[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(O)(C3=CC=CC=C3)C4=CC=CC=C4
InChI
InChIKey=OATDVDIMNNZTEY-XWALJWNASA-N
InChI=1S/C24H29FNO3/c1-26(15-14-25)20-12-13-21(26)17-22(16-20)29-23(27)24(28,18-8-4-2-5-9-18)19-10-6-3-7-11-19/h2-11,20-22,28H,12-17H2,1H3/q+1/t20-,21+,22+,26?
| Molecular Formula | C24H28FNO3 |
| Molecular Weight | 397.4824 |
| Charge | 0 |
| Count |
|
| Stereochemistry | EPIMERIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 3 / 4 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
DescriptionCurator's Comment: description was created based on several sources, including:
http://en.pharmacodia.com/web/drug/1_10230.html | https://www.ncbi.nlm.nih.gov/pubmed/7886652 | https://www.ncbi.nlm.nih.gov/pubmed/2431695
Curator's Comment: description was created based on several sources, including:
http://en.pharmacodia.com/web/drug/1_10230.html | https://www.ncbi.nlm.nih.gov/pubmed/7886652 | https://www.ncbi.nlm.nih.gov/pubmed/2431695
The anticholinergic agent Flutropium is a classic competitive antagonist of acetylcholine. In in vitro experiments it is more effective than atropine. A poor enteral absorption is to be expected; this can be concluded from the low relative effectiveness after oral administration. After local administration as an aerosol it is superior to atropine with regard to both effectiveness and duration of action. It is used in Japan to treat asthma and chronic obstructive pulmonary disease. Flutropium can be described as a preparation which is free of side effects.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Palliative | FLUBRON Approved UseIt has been used for the relief of symptoms of bronchial asthma and COPD. |
|||
| Palliative | FLUBRON Approved UseIt has been used for the relief of symptoms of bronchial asthma and COPD. |
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Effects of flutropium bromide, a new antiasthma drug, with repeated administration on bronchomotor response and hepatic drug metabolizing enzymes]. | 1989-06 |
|
| [Effects of flutropium bromide, a new antiasthma drug, on mediator release from mast cells and actions of mediators]. | 1988-02 |
|
| Pharmacology of the anticholinergic bronchospasmolytic agent flutropium bromide. | 1986-09 |
|
| Synthesis of the bronchospasmolytic agent flutropium bromide and of some homologous and configuration isomeric compounds. | 1986-08 |
|
| Molecular and crystal structure of flutropium bromide. | 1986-08 |
|
| Effects of 8-(2-fluoroethyl)-3 alpha-hydroxy-1 alpha H, 5 alpha H-tropaniumbromide benzilate (Ba598Br) on allergy- and drug-induced asthmas. | 1983-10 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:23:48 GMT 2025
by
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on
Mon Mar 31 18:23:48 GMT 2025
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| Record UNII |
TA73FX29II
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| Record Status |
Validated (UNII)
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| Record Version |
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NCI_THESAURUS |
C29704
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C87639
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