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Details

Stereochemistry ABSOLUTE
Molecular Formula C6H12O6
Molecular Weight 180.1559
Optical Activity ( - )
Defined Stereocenters 3 / 3
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TAGATOSE

SMILES

OC[C@@H](O)[C@H](O)[C@H](O)C(=O)CO

InChI

InChIKey=BJHIKXHVCXFQLS-PQLUHFTBSA-N
InChI=1S/C6H12O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3,5-9,11-12H,1-2H2/t3-,5+,6-/m1/s1

HIDE SMILES / InChI

Molecular Formula C6H12O6
Molecular Weight 180.1559
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 3 / 3
E/Z Centers 0
Optical Activity UNSPECIFIED

Tagatose is a functional sweetener. It is naturally occurring and often found in dairy products. Tagatose is similar in texture and sweetness to sucrose (table sugar) but with only 38% of the calories. It is approved for use as a food additive as a low-calorie sweetener. Only 15 - 20 % of Tagatose is absorbed in the small intestines and metabolized similarly to sucrose; the bulk of ingested tagatose is fermented in the colon by bacteria producing short chain fatty acids which are subsequently absorbed and metabolized by the body without affecting insulin levels. Tagatose is being investigated by Spherix for the treatment of obesity and type II diabetes. Tagatose consumed orally significantly blunts the rise in plasma glucose seen after oral glucose in patients with diabetes mellitus in a dose-dependent manner without significantly affecting insulin levels. It has been suggested that Tagatose may act by attenuating the absorption of glucose in the intestines.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Sourcing

Sourcing

Vendor/AggregatorIDURL

Sample Use Guides

Patients with type II diabetes were instructed to consume 15 grams of tagatose dissolved in water every day for one year.
Route of Administration: Oral
A clinically isolated strain of Streptococcus mutans GS5 was grown in TY medium at 37 deg-C for 24 hours. After 24 hours the culture was diluted to OD600 = 0.3 and inoculated into a solution of 10% w/v Tagatose in TY medium (with and without 1% w/v sucrose). The inoculated tagatose solution was incubated at 37 deg C and OD600 measured at 4, 8, 12, and 20 hours. The pH of the inoculated solution was measured at 12 hours. d-tagatose significantly inhibited the acid production and water-insoluble glucan synthesis of GS5 in the presence of 1% sucrose, and the inhibitory effect of acid production by D-tagatose was significantly stronger that of xylitol in presence of sucrose.
Substance Class Chemical
Created
by admin
on Wed Jul 05 22:45:07 UTC 2023
Edited
by admin
on Wed Jul 05 22:45:07 UTC 2023
Record UNII
T7A20Y888Y
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TAGATOSE
MART.   USP-RS  
Systematic Name English
TAGATOSE [MART.]
Common Name English
TAGATOSE [USP-RS]
Common Name English
TAGATOSE, D-
II  
Systematic Name English
D-LYXO-HEXULOSE
Common Name English
NATURLOSE
Brand Name English
TAGATOSE, D- [II]
Common Name English
D-TAGATOSE [FCC]
Common Name English
D-TAGATOSE [MI]
Common Name English
D-TAGATOSE
FCC   MI  
Systematic Name English
D-(-)-TAGATOSE
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 459614
Created by admin on Wed Jul 05 22:45:07 UTC 2023 , Edited by admin on Wed Jul 05 22:45:07 UTC 2023
Code System Code Type Description
WIKIPEDIA
Tagatose
Created by admin on Wed Jul 05 22:45:07 UTC 2023 , Edited by admin on Wed Jul 05 22:45:07 UTC 2023
PRIMARY
CHEBI
47693
Created by admin on Wed Jul 05 22:45:07 UTC 2023 , Edited by admin on Wed Jul 05 22:45:07 UTC 2023
PRIMARY
CHEBI
4249
Created by admin on Wed Jul 05 22:45:07 UTC 2023 , Edited by admin on Wed Jul 05 22:45:07 UTC 2023
PRIMARY
GRAS Notification (GRN No.)
78
Created by admin on Wed Jul 05 22:45:07 UTC 2023 , Edited by admin on Wed Jul 05 22:45:07 UTC 2023
PRIMARY
RS_ITEM_NUM
1642904
Created by admin on Wed Jul 05 22:45:07 UTC 2023 , Edited by admin on Wed Jul 05 22:45:07 UTC 2023
PRIMARY
MERCK INDEX
M10431
Created by admin on Wed Jul 05 22:45:07 UTC 2023 , Edited by admin on Wed Jul 05 22:45:07 UTC 2023
PRIMARY Merck Index
EPA CompTox
DTXSID3047897
Created by admin on Wed Jul 05 22:45:07 UTC 2023 , Edited by admin on Wed Jul 05 22:45:07 UTC 2023
PRIMARY
GRAS Notification (GRN No.)
977
Created by admin on Wed Jul 05 22:45:07 UTC 2023 , Edited by admin on Wed Jul 05 22:45:07 UTC 2023
PRIMARY
MESH
C030192
Created by admin on Wed Jul 05 22:45:07 UTC 2023 , Edited by admin on Wed Jul 05 22:45:07 UTC 2023
PRIMARY
PUBCHEM
92092
Created by admin on Wed Jul 05 22:45:07 UTC 2023 , Edited by admin on Wed Jul 05 22:45:07 UTC 2023
PRIMARY
FDA UNII
T7A20Y888Y
Created by admin on Wed Jul 05 22:45:07 UTC 2023 , Edited by admin on Wed Jul 05 22:45:07 UTC 2023
PRIMARY
EVMPD
SUB26542
Created by admin on Wed Jul 05 22:45:07 UTC 2023 , Edited by admin on Wed Jul 05 22:45:07 UTC 2023
PRIMARY
CHEBI
16443
Created by admin on Wed Jul 05 22:45:07 UTC 2023 , Edited by admin on Wed Jul 05 22:45:07 UTC 2023
PRIMARY
CAS
41847-61-4
Created by admin on Wed Jul 05 22:45:07 UTC 2023 , Edited by admin on Wed Jul 05 22:45:07 UTC 2023
ALTERNATIVE
EVMPD
SUB129913
Created by admin on Wed Jul 05 22:45:07 UTC 2023 , Edited by admin on Wed Jul 05 22:45:07 UTC 2023
PRIMARY
ECHA (EC/EINECS)
201-772-3
Created by admin on Wed Jul 05 22:45:07 UTC 2023 , Edited by admin on Wed Jul 05 22:45:07 UTC 2023
PRIMARY
CAS
41847-01-2
Created by admin on Wed Jul 05 22:45:07 UTC 2023 , Edited by admin on Wed Jul 05 22:45:07 UTC 2023
ALTERNATIVE
SMS_ID
100000091290
Created by admin on Wed Jul 05 22:45:07 UTC 2023 , Edited by admin on Wed Jul 05 22:45:07 UTC 2023
PRIMARY
DRUG BANK
DB04936
Created by admin on Wed Jul 05 22:45:07 UTC 2023 , Edited by admin on Wed Jul 05 22:45:07 UTC 2023
PRIMARY
CAS
87-81-0
Created by admin on Wed Jul 05 22:45:07 UTC 2023 , Edited by admin on Wed Jul 05 22:45:07 UTC 2023
PRIMARY
GRAS Notification (GRN No.)
352
Created by admin on Wed Jul 05 22:45:07 UTC 2023 , Edited by admin on Wed Jul 05 22:45:07 UTC 2023
PRIMARY
Related Record Type Details
TARGET -> ACTIVATOR
Related Record Type Details
ACTIVE MOIETY