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Details

Stereochemistry ACHIRAL
Molecular Formula C12H14N4O3S
Molecular Weight 294.33
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SULFACYTINE

SMILES

CCN1C=CC(NS(=O)(=O)C2=CC=C(N)C=C2)=NC1=O

InChI

InChIKey=SIBQAECNSSQUOD-UHFFFAOYSA-N
InChI=1S/C12H14N4O3S/c1-2-16-8-7-11(14-12(16)17)15-20(18,19)10-5-3-9(13)4-6-10/h3-8H,2,13H2,1H3,(H,14,15,17)

HIDE SMILES / InChI

Molecular Formula C12H14N4O3S
Molecular Weight 294.33
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Sulfacytine is a short-acting sulfonamide, which was used for the treatment uncomplicated urinary tract infections, but was discontinued. This drug is a is a competitive inhibitor of the dihydropteroate synthetase, that inhibits bacterial synthesis of dihydrofolic acid by preventing the condensation of the peridine with para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase.

CNS Activity

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
RENOQUID

T1/2

ValueDoseCo-administeredAnalytePopulation
4 h
1 g single, oral
SULFACYTINE plasma
Homo sapiens

Funbound

ValueDoseCo-administeredAnalytePopulation
14%
1 g single, oral
SULFACYTINE plasma
Homo sapiens

PubMed

Patents

Sample Use Guides

In Vivo Use Guide
1Gm per day
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Record UNII
T795873AJP
Record Status Validated (UNII)
Record Version