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Details

Stereochemistry ACHIRAL
Molecular Formula C18H25N3O5
Molecular Weight 363.4082
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CAROCAINIDE

SMILES

CNC(=O)NC1=C(OCCN2CCCC2)C(OC)=C3OC=CC3=C1OC

InChI

InChIKey=BWMMRMDCODVQBX-UHFFFAOYSA-N
InChI=1S/C18H25N3O5/c1-19-18(22)20-13-14(23-2)12-6-10-25-15(12)17(24-3)16(13)26-11-9-21-7-4-5-8-21/h6,10H,4-5,7-9,11H2,1-3H3,(H2,19,20,22)

HIDE SMILES / InChI

Molecular Formula C18H25N3O5
Molecular Weight 363.4082
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Carocainide is a benzofuran derivative patented by pharmaceutical company Delalande S. A. For treatment cardiovascular disease. Carocainide showing antiarrhythmic properties in animal models. In isolated papillary muscles and Purkinje fibers it decreases the maximum rate of rise of the action potential and in Purkinje fibers it decreases the plateau amplitude and the duration of the action potential. Carocainide increases the ratio of the effective refractory period to the action potential duration at 90% of repolarization, shifts the membrane responsiveness curve towards more negative membrane potentials and slows down the recovery of the maximum rate of rise of the action potentials of the Purkinje fibers. Carocainide also increases the conduction time at the Purkinje papillary muscle junction.

Approval Year

PubMed

PubMed

TitleDatePubMed
Synthesis and antiarrhythmic activity of new benzofuran derivatives.
1981 Feb
Patents

Patents

Sample Use Guides

3.5 mg/kg
Route of Administration: Intravenous
Substance Class Chemical
Created
by admin
on Sat Dec 16 16:52:12 GMT 2023
Edited
by admin
on Sat Dec 16 16:52:12 GMT 2023
Record UNII
T643E80J9K
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CAROCAINIDE
INN  
INN  
Official Name English
carocainide [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C47793
Created by admin on Sat Dec 16 16:52:12 GMT 2023 , Edited by admin on Sat Dec 16 16:52:12 GMT 2023
Code System Code Type Description
ChEMBL
CHEMBL289192
Created by admin on Sat Dec 16 16:52:12 GMT 2023 , Edited by admin on Sat Dec 16 16:52:12 GMT 2023
PRIMARY
EVMPD
SUB06135MIG
Created by admin on Sat Dec 16 16:52:12 GMT 2023 , Edited by admin on Sat Dec 16 16:52:12 GMT 2023
PRIMARY
MESH
C038839
Created by admin on Sat Dec 16 16:52:12 GMT 2023 , Edited by admin on Sat Dec 16 16:52:12 GMT 2023
PRIMARY
EPA CompTox
DTXSID00216381
Created by admin on Sat Dec 16 16:52:12 GMT 2023 , Edited by admin on Sat Dec 16 16:52:12 GMT 2023
PRIMARY
PUBCHEM
71970
Created by admin on Sat Dec 16 16:52:12 GMT 2023 , Edited by admin on Sat Dec 16 16:52:12 GMT 2023
PRIMARY
ECHA (EC/EINECS)
266-233-7
Created by admin on Sat Dec 16 16:52:12 GMT 2023 , Edited by admin on Sat Dec 16 16:52:12 GMT 2023
PRIMARY
SMS_ID
100000081342
Created by admin on Sat Dec 16 16:52:12 GMT 2023 , Edited by admin on Sat Dec 16 16:52:12 GMT 2023
PRIMARY
NCI_THESAURUS
C77979
Created by admin on Sat Dec 16 16:52:12 GMT 2023 , Edited by admin on Sat Dec 16 16:52:12 GMT 2023
PRIMARY
INN
5049
Created by admin on Sat Dec 16 16:52:12 GMT 2023 , Edited by admin on Sat Dec 16 16:52:12 GMT 2023
PRIMARY
FDA UNII
T643E80J9K
Created by admin on Sat Dec 16 16:52:12 GMT 2023 , Edited by admin on Sat Dec 16 16:52:12 GMT 2023
PRIMARY
CAS
66203-00-7
Created by admin on Sat Dec 16 16:52:12 GMT 2023 , Edited by admin on Sat Dec 16 16:52:12 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY