Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C12H6ClF3N4O3 |
| Molecular Weight | 346.649 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)C1=CN(N=C1)C2=NC3=CC(OC(F)(F)F)=C(Cl)C=C3N2
InChI
InChIKey=FXHHASJVTYRJHH-UHFFFAOYSA-N
InChI=1S/C12H6ClF3N4O3/c13-6-1-7-8(2-9(6)23-12(14,15)16)19-11(18-7)20-4-5(3-17-20)10(21)22/h1-4H,(H,18,19)(H,21,22)
| Molecular Formula | C12H6ClF3N4O3 |
| Molecular Weight | 346.649 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
JNJ 42041935 is a potent, 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes. Administration of JNJ-42041935 to rats for 5 consecutive days resulted in a 2-fold increase in reticulocytes, an increase in hemoglobin, and an increase in the hematocrit. It may be an effective means to treat anemia of various origin, in which current treatments are ineffective or not optimal.
Originator
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 09:06:15 GMT 2023
by
admin
on
Sat Dec 16 09:06:15 GMT 2023
|
| Record UNII |
T4PPL01131
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
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Systematic Name | English |
| Code System | Code | Type | Description | ||
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45102710
Created by
admin on Sat Dec 16 09:06:15 GMT 2023 , Edited by admin on Sat Dec 16 09:06:15 GMT 2023
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1193383-09-3
Created by
admin on Sat Dec 16 09:06:15 GMT 2023 , Edited by admin on Sat Dec 16 09:06:15 GMT 2023
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PRIMARY | |||
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T4PPL01131
Created by
admin on Sat Dec 16 09:06:15 GMT 2023 , Edited by admin on Sat Dec 16 09:06:15 GMT 2023
|
PRIMARY |
| Related Record | Type | Details | ||
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ACTIVE MOIETY |
