Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C12H6ClF3N4O3 |
| Molecular Weight | 346.649 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)C1=CN(N=C1)C2=NC3=C(N2)C=C(Cl)C(OC(F)(F)F)=C3
InChI
InChIKey=FXHHASJVTYRJHH-UHFFFAOYSA-N
InChI=1S/C12H6ClF3N4O3/c13-6-1-7-8(2-9(6)23-12(14,15)16)19-11(18-7)20-4-5(3-17-20)10(21)22/h1-4H,(H,18,19)(H,21,22)
| Molecular Formula | C12H6ClF3N4O3 |
| Molecular Weight | 346.649 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
JNJ 42041935 is a potent, 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes. Administration of JNJ-42041935 to rats for 5 consecutive days resulted in a 2-fold increase in reticulocytes, an increase in hemoglobin, and an increase in the hematocrit. It may be an effective means to treat anemia of various origin, in which current treatments are ineffective or not optimal.
Originator
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 22:29:48 GMT 2025
by
admin
on
Mon Mar 31 22:29:48 GMT 2025
|
| Record UNII |
T4PPL01131
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
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45102710
Created by
admin on Mon Mar 31 22:29:48 GMT 2025 , Edited by admin on Mon Mar 31 22:29:48 GMT 2025
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1193383-09-3
Created by
admin on Mon Mar 31 22:29:48 GMT 2025 , Edited by admin on Mon Mar 31 22:29:48 GMT 2025
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T4PPL01131
Created by
admin on Mon Mar 31 22:29:48 GMT 2025 , Edited by admin on Mon Mar 31 22:29:48 GMT 2025
|
PRIMARY |
| Related Record | Type | Details | ||
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