MAT2A-IN-9

Details

Stereochemistry	RACEMIC
Molecular Formula	C14H8ClF3N4O
Molecular Weight	340.688
Optical Activity	( + / - )
Additional Stereochemistry	Yes
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0
Stereo Comments	AXIAL, RACEMIC

SHOW SMILES / InChI

Structure Search

SMILES

NC1=NC(=O)N(C2=CC=CC=C2Cl)C3=C1C=CC(=N3)C(F)(F)F

InChI

InChIKey=BVNKURJMNQNVAO-UHFFFAOYSA-N

InChI=1S/C14H8ClF3N4O/c15-8-3-1-2-4-9(8)22-12-7(11(19)21-13(22)23)5-6-10(20-12)14(16,17)18/h1-6H,(H2,19,21,23)

HIDE SMILES / InChI

Molecular Formula	C14H8ClF3N4O
Molecular Weight	340.688
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Wed Apr 02 11:40:16 GMT 2025` Edited by `admin` on `Wed Apr 02 11:40:16 GMT 2025`
Record UNII	T46P23PK39
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MAT2A-IN-9

Common Name

English

IDE-397

Preferred Name

English

4-AMINO-1-(2-CHLOROPHENYL)-7-(TRIFLUOROMETHYL)PYRIDO(2,3-D)PYRIMIDIN-2(1H)-ONE

Systematic Name

English

Pyrido[2,3-d]pyrimidin-2(1H)-one, 4-amino-1-(2-chlorophenyl)-7-(trifluoromethyl)-

Systematic Name

English

Code System Code Type Description

PUBCHEM

153608878

Created by admin on Wed Apr 02 11:40:16 GMT 2025 , Edited by admin on Wed Apr 02 11:40:16 GMT 2025

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FDA UNII

T46P23PK39

Created by admin on Wed Apr 02 11:40:16 GMT 2025 , Edited by admin on Wed Apr 02 11:40:16 GMT 2025

PRIMARY

CAS

2439277-80-0

Created by admin on Wed Apr 02 11:40:16 GMT 2025 , Edited by admin on Wed Apr 02 11:40:16 GMT 2025

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Related Record Type Details


					T46P23PK39

MAT2A-IN-9

ACTIVE MOIETY

Comments:

Overall, both atropisomers are highly potent inhibitors of MAT2A biochemical activity and generally show similar potency to each other and to IDE397 in the cellular anti-proliferation assays across cell lines.

Amount: