Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C8H15NO6 |
Molecular Weight | 221.2078 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 5 / 5 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O
InChI
InChIKey=OVRNDRQMDRJTHS-PVFLNQBWSA-N
InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-,8+/m1/s1
Molecular Formula | C8H15NO6 |
Molecular Weight | 221.2078 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 5 / 5 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/14551185Curator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/23430107 | https://www.ncbi.nlm.nih.gov/pubmed/19006331 | https://www.ncbi.nlm.nih.gov/pubmed/7305946 | https://www.ncbi.nlm.nih.gov/pubmed/7759502
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14551185
Curator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/23430107 | https://www.ncbi.nlm.nih.gov/pubmed/19006331 | https://www.ncbi.nlm.nih.gov/pubmed/7305946 | https://www.ncbi.nlm.nih.gov/pubmed/7759502
N-Acetyl-α-D-glucosamine (alpha-GlcNAc) is a major component of complex carbohydrates, that has been found in N- and O-glycans and glycolipids. Glycosaminoglycans and the glycosylphosphatidylinositol anchor of membrane-bound glycoproteins also contain GlcNAc moieties. GlcNAc is derived from the degradation of glycoconjugates by glycosidases and from nutritional sources. GlcNAc is converted into GlcNAc-6-phosphate by the N-acetylglucosamine kinase. GlcNAc-6-phosphate can enter a catabolic pathway that ultimately leads to the formation of fructose-6-phosphate, or it can enter an anabolic pathway leading to the formation of UDP-GlcNAc.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL1932892 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7305946 |
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Target ID: Q9UJ70 Gene ID: 55577.0 Gene Symbol: NAGK Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/19006331 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
Sample Use Guides
In Vivo Use Guide
Sources: https://clinicaltrials.gov/ct2/show/NCT02504060
During the 12- weeks treatment phase of the study, the daily dose of 100mg*3 (3 tablets) will be taken 30 minutes after breakfast, lunch and supper.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/10649686
The effect of N-acetylglucosamine (NAG) on in vitro synthesis of glycosaminoglycans by human peritoneal mesothelial cells and fibroblasts was studied. In contrast to isosmotic concentrations of glucose, NAG increases the synthesis of hyaluronan by mesothelial cells and fibroblasts in a dose-dependent manner. Glucose inhibits synthesis of sulphated glycosaminoglycans by peritoneal mesothelial cells and fibroblasts, whereas NAG stimulates their production. It was demonstrated that NAG was an effective stimulator of the in vitro glycosaminoglycans synthesis by human peritoneal mesothelial cells and fibroblasts.
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:24:37 GMT 2023
by
admin
on
Fri Dec 15 16:24:37 GMT 2023
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Record UNII |
T13TI5GH3D
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Record Status |
Validated (UNII)
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Record Version |
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