CLOPREDNOL

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H25ClO5
Molecular Weight	392.873
Optical Activity	UNSPECIFIED
Defined Stereocenters	7 / 7
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3([H])[C@@]2([H])C=C(Cl)C4=CC(=O)C=C[C@]34C

InChI

InChIKey=YTJIBEDMAQUYSZ-FDNPDPBUSA-N

InChI=1S/C21H25ClO5/c1-19-5-3-11(24)7-14(19)15(22)8-12-13-4-6-21(27,17(26)10-23)20(13,2)9-16(25)18(12)19/h3,5,7-8,12-13,16,18,23,25,27H,4,6,9-10H2,1-2H3/t12-,13-,16-,18+,19-,20-,21-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C21H25ClO5
Molecular Weight	392.873
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	7 / 7
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6374803

Cloprednol is a steroid, which was used for the treatment of asthma. The exact mechanism of cloprednol action is unknown. The drug was marketed under several names, including Syntestan and Cloradryn, however, its current marketing status is unknown and supposed to be discontinued.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Asthma 241 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6374803	Palliative		Approved 8429	SYNTESTAN Approved Use Asthma.

PubMed

Title	Date	PubMed
Comparison of cloprednol and prednisolone in chronic asthmatic patients.	1978 Jul	352380

Patents

Sample Use Guides

In Vivo Use Guide

Cloprednol is given as a single morning dose of 5-12.5 mg orally.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 18:01:57 GMT 2023` Edited by `admin` on `Sat Dec 16 18:01:57 GMT 2023`
Record UNII	SYP56O3GJG
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CLOPREDNOL

Official Name

English

CLOPREDNOL [MI]

Common Name

English

6-Chloro-11β,17,21-trihydroxypregna-1,4,6-triene-3,20-dione

Systematic Name

English

RS-4691

Code

English

CLORADRYN

Brand Name

English

PREGNA-1,4,6-TRIENE-3,20-DIONE, 6-CHLORO-11,17,21-TRIHYDROXY-, (11.BETA.)-

Systematic Name

English

Cloprednol [WHO-DD]

Common Name

English

CLOPREDNOL [USAN]

Common Name

English

cloprednol [INN]

Common Name

English

CLOPREDNOL [MART.]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QH02AB14