CLOPREDNOL

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H25ClO5
Molecular Weight	392.873
Optical Activity	UNSPECIFIED
Defined Stereocenters	7 / 7
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@]12C[C@H](O)[C@H]3[C@@H](C=C(Cl)C4=CC(=O)C=C[C@]34C)[C@@H]1CC[C@]2(O)C(=O)CO

InChI

InChIKey=YTJIBEDMAQUYSZ-FDNPDPBUSA-N

InChI=1S/C21H25ClO5/c1-19-5-3-11(24)7-14(19)15(22)8-12-13-4-6-21(27,17(26)10-23)20(13,2)9-16(25)18(12)19/h3,5,7-8,12-13,16,18,23,25,27H,4,6,9-10H2,1-2H3/t12-,13-,16-,18+,19-,20-,21-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C21H25ClO5
Molecular Weight	392.873
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	7 / 7
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6374803

Cloprednol is a steroid, which was used for the treatment of asthma. The exact mechanism of cloprednol action is unknown. The drug was marketed under several names, including Syntestan and Cloradryn, however, its current marketing status is unknown and supposed to be discontinued.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Asthma 244 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6374803	Palliative		Approved 8583	SYNTESTAN Approved Use Asthma.

C_max

Value	Dose	Co-administered	Analyte	Population
41.3 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/660508/	2.5 mg single, oral dose: 2.5 mg route of administration: Oral experiment type: SINGLE co-administered:		CLOPREDNOL plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
426 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/3403094/	20 mg single, oral dose: 20 mg route of administration: Oral experiment type: SINGLE co-administered:		CLOPREDNOL plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN

AUC

Value	Dose	Co-administered	Analyte	Population
126 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/660508/	2.5 mg single, oral dose: 2.5 mg route of administration: Oral experiment type: SINGLE co-administered:		CLOPREDNOL plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED

T_1/2

Value	Dose	Co-administered	Analyte	Population
1.87 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/660508/	2.5 mg single, oral dose: 2.5 mg route of administration: Oral experiment type: SINGLE co-administered:		CLOPREDNOL plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED

F_unbound

Value	Dose	Co-administered	Analyte	Population
16% EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/3403094/	20 mg single, oral dose: 20 mg route of administration: Oral experiment type: SINGLE co-administered:		CLOPREDNOL plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN

Doses

Dose	Population	Adverse events
12.5 mg 1 times / day multiple, oral Highest studied dose Dose: 12.5 mg, 1 times / day Route: oral Route: multiple Dose: 12.5 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/6374803/	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/6374803/	Sources: https://pubmed.ncbi.nlm.nih.gov/6374803/

PubMed

Title	Date	PubMed
Comparison of cloprednol and prednisolone in chronic asthmatic patients.	1978-07	352380

Patents

Sample Use Guides

In Vivo Use Guide

Cloprednol is given as a single morning dose of 5-12.5 mg orally.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Wed Apr 02 09:57:07 GMT 2025` Edited by `admin` on `Wed Apr 02 09:57:07 GMT 2025`
Record UNII	SYP56O3GJG
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CLORADRYN

Preferred Name

English

CLOPREDNOL

Official Name

English

CLOPREDNOL [MI]

Common Name

English

6-Chloro-11?,17,21-trihydroxypregna-1,4,6-triene-3,20-dione

Systematic Name

English

RS-4691

Code

English

PREGNA-1,4,6-TRIENE-3,20-DIONE, 6-CHLORO-11,17,21-TRIHYDROXY-, (11.BETA.)-

Systematic Name

English

Cloprednol [WHO-DD]

Common Name

English

CLOPREDNOL [USAN]

Common Name

English

cloprednol [INN]

Common Name

English

CLOPREDNOL [MART.]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QH02AB14