Details
Stereochemistry | ACHIRAL |
Molecular Formula | C15H29N3O2 |
Molecular Weight | 283.4097 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)CC(=O)N1CCN(CC1)C(=O)CCCCCN
InChI
InChIKey=VRZYMMVEALDDBH-UHFFFAOYSA-N
InChI=1S/C15H29N3O2/c1-13(2)12-15(20)18-10-8-17(9-11-18)14(19)6-4-3-5-7-16/h13H,3-12,16H2,1-2H3
Molecular Formula | C15H29N3O2 |
Molecular Weight | 283.4097 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: P55085 Gene ID: 2150.0 Gene Symbol: F2RL1 Target Organism: Homo sapiens (Human) |
1.2 mM [IC50] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
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Primary | Unknown Approved UseUnknown |
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Primary | Unknown Approved UseUnknown |
Sample Use Guides
In a preclinical testing (arthritis model), ENMD-1068 was given intraperitoneally at doses of 1 and 4 mg to wild-type mice. In the preclinical model of liver fibrosis and endometriosis, mice were injected intraperitoneally with either 25 mg/kg or 50 mg/kg ENMD-1068.
Route of Administration:
Intraperitoneal
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/16260582
Murine Lewis lung carcinoma cells were incubated with increasing concentrations of ENMD-1068 for 30-40 min and then stimulated with 200 uM SLIGKV-NH2. ENMD-1068 dose-dependently inhibited calcium signaling, this being complete at 5 mM.
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:28:32 GMT 2023
by
admin
on
Sat Dec 16 08:28:32 GMT 2023
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Record UNII |
STV44CBK1W
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Record Status |
Validated (UNII)
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Record Version |
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STV44CBK1W
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admin on Sat Dec 16 08:28:32 GMT 2023 , Edited by admin on Sat Dec 16 08:28:32 GMT 2023
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Related Record | Type | Details | ||
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ACTIVE MOIETY |