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Details

Stereochemistry ABSOLUTE
Molecular Formula C6H8O8.Ca
Molecular Weight 248.201
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CALCIUM SACCHARATE ANHYDROUS

SMILES

[Ca++].O[C@@H]([C@H](O)[C@@H](O)C([O-])=O)[C@H](O)C([O-])=O

InChI

InChIKey=UGZVNIRNPPEDHM-SBBOJQDXSA-L
InChI=1S/C6H10O8.Ca/c7-1(3(9)5(11)12)2(8)4(10)6(13)14;/h1-4,7-10H,(H,11,12)(H,13,14);/q;+2/p-2/t1-,2-,3-,4+;/m0./s1

HIDE SMILES / InChI

Molecular Formula C6H8O8
Molecular Weight 208.1229
Charge -2
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED

Molecular Formula Ca
Molecular Weight 40.078
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Calcium-D-glucarate (also known as CALCIUM SACCHARATE) is the calcium salt of D-glucaric acid, a substance produced naturally in small amounts by mammals, including humans. Oral supplementation of calcium-D-glucarate has been shown to inhibit beta-glucuronidase, an enzyme produced by colonic microflora and involved in Phase II liver detoxification. Elevated beta-glucuronidase activity is associated with an increased risk for various cancers, particularly hormone-dependent cancers such as breast, prostate, and colon cancers. Other potential clinical applications of oral calcium-D-glucarate include regulation of estrogen metabolism and as a lipid-lowering. In addition, by reducing the beta-glucuronidase viability and activity of intestinal bacteria, salts of D-glucaric acid have been shown to enhance enterohepatic circulation and reduce steady state levels of cholesterol synthesis, resulting in decreased serum lipid levels.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Unknown

Approved Use

Unknown
Palliative
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Calcium-D-glucarate.
2002 Aug

Sample Use Guides

Take 1 to 3 caps 3 times daily with meals
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:33:23 GMT 2023
Edited
by admin
on Fri Dec 15 16:33:23 GMT 2023
Record UNII
SST07NLK7J
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CALCIUM SACCHARATE ANHYDROUS
Common Name English
CALCIUM D-GLUCARATE
Common Name English
Calcium saccharate [WHO-DD]
Common Name English
CALCIUM GLUCARATE
Common Name English
CALCIUM D-GLUCARATE (1:1)
Common Name English
CALCIUM D-SACCHARATE [VANDF]
Common Name English
calcium saccharate [INN]
Common Name English
SACCHARATED LIME [INCI]
Common Name English
D-GLUCARIC ACID, CALCIUM SALT (1:1)
Common Name English
Calcium glucarate [WHO-DD]
Common Name English
NSC-122011
Code English
SACCHARATED LIME
INCI  
INCI  
Official Name English
D-GLUCARIC ACID CALCIUM SALT
Common Name English
CALCIUM D-SACCHARATE [MI]
Common Name English
CALCIUM D-SACCHARATE
MI   VANDF  
Common Name English
Classification Tree Code System Code
DSLD 1108 (Number of products:5)
Created by admin on Fri Dec 15 16:33:23 GMT 2023 , Edited by admin on Fri Dec 15 16:33:23 GMT 2023
NCI_THESAURUS C1017
Created by admin on Fri Dec 15 16:33:23 GMT 2023 , Edited by admin on Fri Dec 15 16:33:23 GMT 2023
DSLD 2385 (Number of products:29)
Created by admin on Fri Dec 15 16:33:23 GMT 2023 , Edited by admin on Fri Dec 15 16:33:23 GMT 2023
DSLD 1681 (Number of products:125)
Created by admin on Fri Dec 15 16:33:23 GMT 2023 , Edited by admin on Fri Dec 15 16:33:23 GMT 2023
Code System Code Type Description
PUBCHEM
154911
Created by admin on Fri Dec 15 16:33:23 GMT 2023 , Edited by admin on Fri Dec 15 16:33:23 GMT 2023
PRIMARY
CAS
5793-88-4
Created by admin on Fri Dec 15 16:33:23 GMT 2023 , Edited by admin on Fri Dec 15 16:33:23 GMT 2023
PRIMARY
ECHA (EC/EINECS)
227-334-1
Created by admin on Fri Dec 15 16:33:23 GMT 2023 , Edited by admin on Fri Dec 15 16:33:23 GMT 2023
PRIMARY
INN
439
Created by admin on Fri Dec 15 16:33:23 GMT 2023 , Edited by admin on Fri Dec 15 16:33:23 GMT 2023
PRIMARY
NCI_THESAURUS
C84483
Created by admin on Fri Dec 15 16:33:23 GMT 2023 , Edited by admin on Fri Dec 15 16:33:23 GMT 2023
PRIMARY
SMS_ID
100000081613
Created by admin on Fri Dec 15 16:33:23 GMT 2023 , Edited by admin on Fri Dec 15 16:33:23 GMT 2023
PRIMARY
EVMPD
SUB06056MIG
Created by admin on Fri Dec 15 16:33:23 GMT 2023 , Edited by admin on Fri Dec 15 16:33:23 GMT 2023
PRIMARY
MERCK INDEX
m2972
Created by admin on Fri Dec 15 16:33:23 GMT 2023 , Edited by admin on Fri Dec 15 16:33:23 GMT 2023
PRIMARY Merck Index
NSC
122011
Created by admin on Fri Dec 15 16:33:23 GMT 2023 , Edited by admin on Fri Dec 15 16:33:23 GMT 2023
PRIMARY
RXCUI
1907
Created by admin on Fri Dec 15 16:33:23 GMT 2023 , Edited by admin on Fri Dec 15 16:33:23 GMT 2023
PRIMARY RxNorm
EPA CompTox
DTXSID70227186
Created by admin on Fri Dec 15 16:33:23 GMT 2023 , Edited by admin on Fri Dec 15 16:33:23 GMT 2023
PRIMARY
FDA UNII
SST07NLK7J
Created by admin on Fri Dec 15 16:33:23 GMT 2023 , Edited by admin on Fri Dec 15 16:33:23 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
SOLVATE->ANHYDROUS