TRAMAZOLINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C13H17N3
Molecular Weight	215.2942
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C1CN=C(NC2=C3CCCCC3=CC=C2)N1

InChI

InChIKey=QQJLHRRUATVHED-UHFFFAOYSA-N

InChI=1S/C13H17N3/c1-2-6-11-10(4-1)5-3-7-12(11)16-13-14-8-9-15-13/h3,5,7H,1-2,4,6,8-9H2,(H2,14,15,16)

HIDE SMILES / InChI

Molecular Formula	C13H17N3
Molecular Weight	215.2942
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.mydr.com.au/medicines/cmis/spray-tish-nasal-spray | https://www.ncbi.nlm.nih.gov/pubmed/23300 | https://www.ncbi.nlm.nih.gov/pubmed/627

Tramazoline is a sympathomimetic drug that is used in the form of tramazoline hydrochloride in nasal decongestant preparations. Tramazoline is an α-adrenergic receptor agonist that inhibits secretion of nasal mucus.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Adrenergic receptor alpha-2 113 Target ID: CHEMBL2093864 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6142954 \| https://www.ncbi.nlm.nih.gov/pubmed/6093449	Agonist 2678		16.0 nM [IC50]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Rhinitis 20 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26539289	Primary		Approved 8429	Spray-Tish Approved Use Spray-Tish is a nasal decongestant. It works by clearing a stuffy or blocked nose by shrinking the inflamed and swollen blood vessels in the lining of the nose. Spray-Tish relieves a stuffy or blocked nose (nasal congestion) associated with the common cold, hayfever and rhinitis. A runny nose, nasal congestion, itching and sneezing, are typical symptoms of a condition known as rhinitis.

PubMed

Title	Date	PubMed
[The tolerability of nasal drugs with special regard to preservatives and physico-chemical parameters].	2003 Nov	14634896
Effects of topical mydriatics and vasoconstrictors on prostaglandin-E2-induced aqueous flare elevation in pigmented rabbits.	2003 Sep-Oct	12920338
The prevalence of allergic asthma and rhinitis in children of Polichni, Thessaloniki.	2004 Mar-Apr	15087091
The effect of nasal steroid administration on intraocular pressure.	2007 Jul	17702318
Tramazoline turns asymptomatic into symptomatic hyper-CK-emia.	2007 Mar	17355540

Patents

Sample Use Guides

In Vivo Use Guide

The recommended dose for adults and children six years of age and over is 1 to 2 sprays into each nostril up to four times daily as required.

Route of Administration: Nasal

In Vitro Use Guide

Binding affinity of Tramazoline against Alpha-2 adrenergic receptor measured as the ability to inhibit the specific [3H]clonidine binding (0.4 nM) to rat isolated brain membranes by 50% was 16 nM.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:14:24 UTC 2023` Edited by `admin` on `Fri Dec 15 15:14:24 UTC 2023`
Record UNII	SLE31693IV
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TRAMAZOLINE

Official Name

English

TRAMAZOLINE [MI]

Common Name

English

2-((5,6,7,8-TETRAHYDRO-1-NAPHTHYL)AMINO)-2-IMIDAZOLINE

Systematic Name

English

Tramazoline [WHO-DD]

Common Name

English

MUCONASAL

Brand Name

English

tramazoline [INN]

Common Name

English

1H-IMIDAZOL-2-AMINE, 4,5-DIHYDRO-N-(5,6,7,8-TETRAHYDRO-1-NAPHTHALENYL)-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29578