2-METHOXYESTRONE

[H][C@@]12CCC(=O)[C@@]1(C)CC[C@]3([H])C4=C(CC[C@@]23[H])C=C(O)C(OC)=C4

InChIKey=WHEUWNKSCXYKBU-QPWUGHHJSA-N

InChI=1S/C19H24O3/c1-19-8-7-12-13(15(19)5-6-18(19)21)4-3-11-9-16(20)17(22-2)10-14(11)12/h9-10,12-13,15,20H,3-8H2,1-2H3/t12-,13+,15-,19-/m0/s1

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

PubMed

Title	Date	PubMed
Metabolism of 2-methoxyestrone in normal men.	1983 Aug	6863476
Altered profile of endogenous steroids in the urine of patients with prolactinoma.	1998 Oct	9812172
Evaluation of an EIA method for measuring serum levels of the estrogen metabolite 2-hydroxyestrone in adults.	2001 Jan	11090660
Inhibition of in vitro angiogenesis by 2-methoxy- and 2-ethyl-estrogen sulfamates.	2004 Apr 20	14991574
Pharmacokinetics and efficacy of 2-methoxyoestradiol and 2-methoxyoestradiol-bis-sulphamate in vivo in rodents.	2004 Feb 23	14970876
The oxidative metabolism of estrogen modulates response to ERT/HRT in postmenopausal women.	2004 Sep	15336604
Selective insensitivity of ZR-75-1 human breast cancer cells to 2-methoxyestradiol: evidence for type II 17beta-hydroxysteroid dehydrogenase as the underlying cause.	2005 Jul 1	15994956
A phase II multicenter, randomized, double-blind, safety trial assessing the pharmacokinetics, pharmacodynamics, and efficacy of oral 2-methoxyestradiol capsules in hormone-refractory prostate cancer.	2005 Sep 15	16166441
The role of 17beta-hydroxysteroid dehydrogenases in modulating the activity of 2-methoxyestradiol in breast cancer cells.	2006 Jan 1	16397246
Analysis of fifteen estrogen metabolites using packed column supercritical fluid chromatography-mass spectrometry.	2006 Mar 1	16503607
Simultaneous determination of eight estrogens and their metabolites in serum using liquid chromatography with electrochemical detection.	2010 Apr 15	20188920

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:11:48 GMT 2023` Edited by `admin` on `Fri Dec 15 15:11:48 GMT 2023`
Record UNII	SJ5857RRL3
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

2-METHOXYESTRONE

Common Name

English

ESTRA-1,3,5(10)-TRIEN-17-ONE, 3-HYDROXY-2-METHOXY-

Systematic Name

English

2-METHOXY-3-HYDROXYESTRA-1,3,5(10)-TRIEN-17-ONE

Systematic Name

English

2-HYDROXYESTRONE 2-METHYL ETHER

Common Name

English

GSS-33

Code

English

2-METHOXY-17-OXOESTRA-1,3,5(10)-TRIEN-3-OL

Systematic Name

English

ESTRONE, 2-METHOXY-

Common Name

English

3-HYDROXY-2-METHOXYESTRA-1,3,5(10)-TRIEN-17-ONE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C2181