INOSINE 5'-SULFATE

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NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C10H12N4O8S
Molecular Weight	348.289
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of INOSINE 5'-SULFATE

Structure Search

SMILES

O[C@@H]1[C@@H](COS(O)(=O)=O)O[C@H]([C@@H]1O)N2C=NC3=C2N=CNC3=O

InChI

InChIKey=IGYLPKLXFDOQGM-KQYNXXCUSA-N

InChI=1S/C10H12N4O8S/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H,18,19,20)/t4-,6-,7-,10-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C10H12N4O8S
Molecular Weight	348.289
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Mon Mar 31 23:27:11 GMT 2025` Edited by `admin` on `Mon Mar 31 23:27:11 GMT 2025`
Record UNII	SJ1W653O6G
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

INO-2002

Preferred Name

English

INOSINE 5'-SULFATE

Systematic Name

English

INOSINE, 5'-(HYDROGEN SULFATE)

Systematic Name

English

5'-IMS

Common Name

English

((2R,3S,4R,5R)-3,4-DIHYDROXY-5-(6-HYDROXYPURIN-9-YL)TETRAHYDROFURAN-2-YL)METHYL HYDROGEN SULFATE

Systematic Name

English

IMS

Common Name

English

Code System Code Type Description

SMS_ID

100000077347

Created by admin on Mon Mar 31 23:27:11 GMT 2025 , Edited by admin on Mon Mar 31 23:27:11 GMT 2025

PRIMARY

CAS

1091624-25-7

Created by admin on Mon Mar 31 23:27:11 GMT 2025 , Edited by admin on Mon Mar 31 23:27:11 GMT 2025

NO STRUCTURE GIVEN

CAS

70023-32-4

Created by admin on Mon Mar 31 23:27:11 GMT 2025 , Edited by admin on Mon Mar 31 23:27:11 GMT 2025

PRIMARY

FDA UNII

SJ1W653O6G

Created by admin on Mon Mar 31 23:27:11 GMT 2025 , Edited by admin on Mon Mar 31 23:27:11 GMT 2025

PRIMARY

DRUG BANK

DB05973

Created by admin on Mon Mar 31 23:27:11 GMT 2025 , Edited by admin on Mon Mar 31 23:27:11 GMT 2025

PRIMARY

PUBCHEM

135494187

Created by admin on Mon Mar 31 23:27:11 GMT 2025 , Edited by admin on Mon Mar 31 23:27:11 GMT 2025

PRIMARY

Related Record Type Details


					PQ675G4NFJ

SODIUM INOSINE 5'-SULFATE

SALT/SOLVATE -> PARENT

Related Record Type Details


					SJ1W653O6G

INOSINE 5'-SULFATE

ACTIVE MOIETY

Comments:

The aim of this study was to determine whether a metabolic resistant purine analog, INO-2002, exerts anti-inflammatory effects in an animal model of acute respiratory distress syndrome. Mice challenged with intratracheal LPS (50 microg) were treated with INO-2002 (30 or 100 mg kg(-1), i.p.) in divided doses at either 1 and 12 h or at 5 and 16 h. After 24 h, bronchoalveolar lavage fluid was obtained to measure leukocyte infiltration by myeloperoxidase levels, lung edema by protein levels, and proinflammatory chemokine (macrophage inflammatory protein 1alpha) and cytokine (TNF-alpha, IL-1, and IL-6) levels. INO-2002 (30 and 100 mg kg(-1)) reduced the LPS-mediated infiltration of leukocytes and edema as evidenced by bronchoalveolar lavage fluid reduction in levels of myeloperoxidase and protein.