Details
Stereochemistry | ACHIRAL |
Molecular Formula | C20H31O2.Na |
Molecular Weight | 326.4487 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 4 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC([O-])=O
InChI
InChIKey=DDMGAAYEUNWXSI-XVSDJDOKSA-M
InChI=1S/C20H32O2.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22;/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22);/q;+1/p-1/b7-6-,10-9-,13-12-,16-15-;
Molecular Formula | C20H31O2 |
Molecular Weight | 303.4589 |
Charge | -1 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 4 |
Optical Activity | NONE |
Molecular Formula | Na |
Molecular Weight | 22.9898 |
Charge | 1 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL239 |
1.2 µM [IC50] | ||
Target ID: CHEMBL235 |
1.6 µM [IC50] | ||
Target ID: CHEMBL3979 |
3.1 µM [IC50] | ||
Target ID: CHEMBL1697668 Sources: https://www.ncbi.nlm.nih.gov/pubmed/23571415 |
602.56 nM [IC50] | ||
Target ID: CHEMBL1743121 Sources: https://www.ncbi.nlm.nih.gov/pubmed/23571415 |
1071.0 nM [IC50] | ||
Target ID: CHEMBL2083 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12036355 |
180.0 nM [Kd] | ||
Target ID: CHEMBL230 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12444669 |
PubMed
Title | Date | PubMed |
---|---|---|
Activation of peroxisome proliferator-activated receptor isoforms and inhibition of prostaglandin H(2) synthases by ibuprofen, naproxen, and indomethacin. | 2001 Dec 15 |
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LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death. | 2002 Jan |
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Antioxidant and pro-oxidant effects of a manganese porphyrin complex against CYP2E1-dependent toxicity. | 2002 Jul 1 |
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Cytosolic phospholipase A2 (cPLA2) regulation of human monocyte NADPH oxidase activity. cPLA2 affects translocation but not phosphorylation of p67(phox) and p47(phox). | 2002 Jul 12 |
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Involvement of CYP2J2 on the intestinal first-pass metabolism of antihistamine drug, astemizole. | 2002 Nov |
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On the interaction of specific prostaglandin H synthase-2 inhibitors with prostaglandin H synthase-1. | 2002 Oct 25 |
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TRA-418, a novel compound having both thromboxane A(2) receptor antagonistic and prostaglandin I(2) receptor agonistic activities: its antiplatelet effects in human and animal platelets. | 2003 Aug |
|
Celecoxib reduces skin damage after radiation: selective reduction of chemokine and receptor mRNA expression in irradiated skin but not in irradiated mammary tumor. | 2003 Aug |
|
Polyunsaturated fatty acid status and relapse vulnerability in cocaine addicts. | 2003 Aug 30 |
|
PPARbeta regulates vitamin A metabolism-related gene expression in hepatic stellate cells undergoing activation. | 2003 Feb |
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Inhibition of prostaglandin H2 synthases by salicylate is dependent on the oxidative state of the enzymes. | 2003 Feb |
|
Aldehyde dehydrogenase 3 expression is decreased by clofibrate via PPAR gamma induction in JM2 rat hepatoma cell line. | 2003 Feb 1 |
|
Metallothionein 2A induction by zinc protects HEPG2 cells against CYP2E1-dependent toxicity. | 2003 Feb 15 |
|
Genetic variation in cyclooxygenase 1: effects on response to aspirin. | 2003 Jan |
|
PGE(2) is generated by specific COX-2 activity and increases VEGF production in COX-2-expressing human pancreatic cancer cells. | 2003 Jul 11 |
|
Eugenol suppresses cyclooxygenase-2 expression in lipopolysaccharide-stimulated mouse macrophage RAW264.7 cells. | 2003 Jun 6 |
|
Effect of the lipid peroxidation product acrolein on tau phosphorylation in neural cells. | 2003 Mar 15 |
|
Role of cytochrome P450-dependent arachidonic acid metabolites in liver physiology and pathophysiology. | 2003 Oct |
|
Prostaglandins and other cyclooxygenase-dependent arachidonic acid metabolites and the kidney in liver disease. | 2003 Oct |
|
Relationship of arachidonic acid concentration to cyclooxygenase-dependent human platelet aggregation. | 2003 Sep |
|
The ingestion of Ginkgo biloba extract (EGb 761) inhibits arachidonic acid-mediated platelet aggregation and thromboxane B2 production in healthy volunteers. | 2004 |
|
Effects of d-003, a new substance purified from sugar cane wax, on platelet aggregation and plasma levels of arachidonic acid metabolites in healthy volunteers. | 2004 |
|
Polyunsaturated fatty acids are FXR ligands and differentially regulate expression of FXR targets. | 2004 Aug |
|
Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1. | 2004 Aug |
|
Preferential inhibition of paraoxonase activity of human paraoxonase 1 by negatively charged lipids. | 2004 Dec |
|
Effects of dietary supplementation with arachidonic acid on platelet and renal function in patients with cirrhosis. | 2004 Jan |
|
Platelet inhibition by aspirin is diminished in patients during carotid surgery: a form of transient aspirin resistance? | 2004 Jul |
|
Peroxisome proliferator-activated receptor and farnesoid X receptor ligands differentially regulate sebaceous differentiation in human sebaceous gland organ cultures in vitro. | 2004 Oct |
|
Glucuronidation of oxidized fatty acids and prostaglandins B1 and E2 by human hepatic and recombinant UDP-glucuronosyltransferases. | 2004 Sep |
|
Regulation and inhibition of arachidonic acid omega-hydroxylases and 20-HETE formation. | 2005 |
|
Polyunsaturated fatty acids block dendritic cell activation and function independently of NF-kappaB activation. | 2005 Apr 8 |
|
Enhanced antiplatelet effect of clopidogrel in patients whose platelets are least inhibited by aspirin: a randomized crossover trial. | 2005 Dec |
|
Increase in heme oxygenase-1 levels ameliorates renovascular hypertension. | 2005 Dec |
|
Cloning, expression, and functional characterization of human cyclooxygenase-1 splicing variants: evidence for intron 1 retention. | 2005 Dec |
|
Fenamates and diltiazem modulate lipid-sensitive mechano-gated 2P domain K(+) channels. | 2005 Dec |
|
A Thrombelastograph whole blood assay for clinical monitoring of NSAID-insensitive transcellular platelet activation by arachidonic acid. | 2005 Jul |
|
Angiotensin II-induced Akt activation through the epidermal growth factor receptor in vascular smooth muscle cells is mediated by phospholipid metabolites derived by activation of phospholipase D. | 2005 Mar |
|
Fatty acids and expression of adipokines. | 2005 May 30 |
|
Specificity of receptor-ligand interactions and their effect on dimerisation as observed by electrospray mass spectrometry: bile acids form stable adducts to the RXRalpha. | 2005 Nov |
|
Matrix metalloproteinases of epithelial origin in facial sebum of patients with acne and their regulation by isotretinoin. | 2005 Oct |
|
Unsaturated fatty acids phosphorylate and destabilize ABCA1 through a phospholipase D2 pathway. | 2005 Oct 28 |
|
Arachidonic acid, an omega-6 fatty acid, induces cytoplasmic phospholipase A2 in prostate carcinoma cells. | 2005 Sep |
|
Induction of CYP1A and cyp2-mediated arachidonic acid epoxygenation and suppression of 20-hydroxyeicosatetraenoic acid by imidazole derivatives including the aromatase inhibitor vorozole. | 2006 Aug |
|
Nongenomic action of progesterone inhibits oxytocin-induced phosphoinositide hydrolysis and prostaglandin F2alpha secretion in the ovine endometrium. | 2006 Feb |
|
Nitric oxide alters arachidonic acid turnover in brain cortex synaptoneurosomes. | 2006 Jan |
|
[Metabolites of arachidonic acid in activating platelets and their estimation by radionuclide techniques]. | 2006 Jan-Apr |
|
Mechanism of induction of muscle protein degradation by angiotensin II. | 2006 Jul |
|
PPARalpha activators and fasting induce the expression of adipose differentiation-related protein in liver. | 2006 May |
|
Metabolites of arachidonic acid in activating platelets and their estimation by radionuclide techniques. | 2006 May-Aug |
|
The inhibitory effect of polyunsaturated fatty acids on human CYP enzymes. | 2006 Nov 25 |
Patents
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:43:55 GMT 2023
by
admin
on
Sat Dec 16 08:43:55 GMT 2023
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Record UNII |
SGR9XN5UVM
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Record Status |
Validated (UNII)
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Record Version |
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-
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SGR9XN5UVM
Created by
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DTXSID001047683
Created by
admin on Sat Dec 16 08:43:56 GMT 2023 , Edited by admin on Sat Dec 16 08:43:56 GMT 2023
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23675453
Created by
admin on Sat Dec 16 08:43:56 GMT 2023 , Edited by admin on Sat Dec 16 08:43:56 GMT 2023
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6610-25-9
Created by
admin on Sat Dec 16 08:43:56 GMT 2023 , Edited by admin on Sat Dec 16 08:43:56 GMT 2023
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PRIMARY |
Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE |
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